Monitoring cancer stem cell dynamics and therapeutic response in BRCA2-deficient breast tumour cells

Project description

Cancer stem cell dynamics in BRCA2-deficient breast cancer

Heterozygous germline mutations in the breast cancer susceptibility genes (BRCA) 1 or 2 predispose to breast, ovarian, pancreatic and prostate cancers. Significant evidence has accumulated in recent years on vulnerabilities specific to BRCA1/2-deficient tumours leading to the development of targeted therapies including poly(ADP-ribose) polymerase (PARP) inhibitors. Recent studies suggest that BRCA2-deficient cells can acquire metastatic and tumour-initiating capacity. The EU-funded BRCAstem project intends to study the relationship between cancer stem cells (CSCs) and the response to PARP inhibitors and ionising radiation in cancer cell lines and patient-derived xenografts lacking BRCA2. This study will uncover the mechanisms driving cell plasticity in models of BRCA2 inactivation and evaluate CSC impact on the response of BRCA-mutated tumours to current targeted therapies.

Fields of science

• medical and health sciences › clinical medicine › oncology › prostate cancer
• natural sciences › physical sciences › nuclear physics
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › clinical medicine › oncology › breast cancer
• natural sciences › biological sciences › genetics › RNA

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Net EU contribution

€ 224 933,76

Address

Wellington Square University Offices
OX1 2JD Oxford
United Kingdom

Region

South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00