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Sizing Up PD: Cavity-enhanced Characterisation of Single Biomarkers in Human Biofluids

Project description

A new diagnostic tool for Parkinson's disease

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the misfolding and aggregation of α-synuclein into Lewy bodies. Understanding how the oligomers formed from this process cause cellular toxicity and disease is paramount to determining the molecular origins of PD. To address this issue, the EU-funded SUPD project will combine spectroscopy and fluorescent technologies to study α-synuclein oligomers in the cerebrospinal fluid of PD patients and healthy individuals. The generated method of measuring α-synuclein oligomer size and structural properties can serve as an early diagnostic tool for PD and may generate opportunities for therapeutic intervention.

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Net EU contribution
€ 289 732,80
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

THE BOARD OF REGENTS OF THE UNIVERSITY OF WISCONSIN SYSTEM
United States
Net EU contribution
€ 0,00
Address
Linden Drive 1220 Vanhise Hall 1860
53706 Madison Wi

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 177 265,92