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Long-lived optical probes to image G-quadruplex DNA in live cells

Project description

Real-time imaging of DNA G-quadruplexes

DNA sequences rich in guanine nucleotides form tetrameric structures known as G-quadruplexes with potential biological roles in telomere function and maintenance, replication and transcription. However, we lack the tools to visualise G-quadruplexes directly in live cells. To address this issue, the EU-funded PLIM-G4 project proposes to develop optical probes that interact with different DNA topologies and upon doing so, their emission lifetime changes in a topology-dependent manner. Optimisation of the properties of these probes will enable the real-time imaging of G-quadruplexes in live cells, allowing to unveil novel information on the role and the dynamics of G-quadruplexes in biological processes.

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Net EU contribution
€ 212 933,76
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00