Enzyme design to clean up synthetic chemistry reactions
There is an overall consensus that greenhouse gas emissions threaten the earth's ecosystem and necessitate immediate mitigating strategies. The EU-funded DENOPHECK project proposes to develop, cleaner and lower-energy reactions through the modification of the most studied coupling reaction recognised by a Nobel prize, the Heck reaction. The Heck reaction uses palladium to facilitate bond formation between carbon atoms and has revolutionised synthetic chemistry. DENOPHECK will undertake de novo protein design to generate novel Heck reaction enzymes that function at ambient temperatures and demonstrate optimal stereoselectivity. The project's findings will advance the chemical methodologies currently used for the synthesis of agrochemical, pharmaceutical and fine chemicals and contribute towards a cleaner planet.
Fields of science
- natural scienceschemical sciencesinorganic chemistrytransition metals
- natural sciencesphysical sciencesastronomyplanetary sciencesplanets
- natural sciencesbiological sciencesecologyecosystems
- natural scienceschemical sciencesinorganic chemistrymetalloids
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes