Project description
Recruiting exosomes for drug delivery to the lung
Exosomes are extracellular vesicles generated from all cells and carry various biomolecules including DNA, lipids and proteins. Their endogenous origin helps them evade immune recognition while their ability to deliver payload at specific target sites renders them ideal for drug delivery. The EU-funded BESG project will engineer exosomes from mesenchymal stem cells to specifically target non-small cell lung carcinoma (NSCLC). The exosomes will deliver an EGFR inhibitor and a specific siRNA against NSCLC and metastasis. Using advanced imaging techniques, scientists will evaluate the pharmacokinetics, biodistribution and anti-cancer activity of exosomes in a mouse model of the disease. The project's results will serve as the foundation for the clinical testing of bioengineered exosomes as a treatment option for lung cancer.
Fields of science
- natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acids
- medical and health sciencesclinical medicineoncologylung cancer
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health scienceshealth sciencespersonalized medicine
- medical and health sciencesbasic medicinepharmacology and pharmacypharmacokinetics
Programme(s)
Funding Scheme
MSCA-IF-EF-SE - Society and Enterprise panelCoordinator
2573 HT 'S-gravenhage
Netherlands
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