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Bioengineered exosomes based approaches for the effective treatment of non-small cell lung cancer

Project description

Recruiting exosomes for drug delivery to the lung

Exosomes are extracellular vesicles generated from all cells and carry various biomolecules including DNA, lipids and proteins. Their endogenous origin helps them evade immune recognition while their ability to deliver payload at specific target sites renders them ideal for drug delivery. The EU-funded BESG project will engineer exosomes from mesenchymal stem cells to specifically target non-small cell lung carcinoma (NSCLC). The exosomes will deliver an EGFR inhibitor and a specific siRNA against NSCLC and metastasis. Using advanced imaging techniques, scientists will evaluate the pharmacokinetics, biodistribution and anti-cancer activity of exosomes in a mouse model of the disease. The project's results will serve as the foundation for the clinical testing of bioengineered exosomes as a treatment option for lung cancer.

Coordinator

PERCUROS BV
Net EU contribution
€ 175 572,48
Address
Eerbeeklaan 42
2573 HT 'S-gravenhage
Netherlands

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Region
West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00