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Identification of molecular targets of psychoactive kavalactones using iBodies

Project description

A novel technology for the identification of natural drug targets

Advances in genomics and metabolomics technologies have rekindled drug discovery efforts using natural chemicals. However, the identification of protein targets of these new bioactive molecules remains laborious. To address this issue, the EU-funded KavaTarget project will design a novel methodology for discovering molecular targets of small molecules using innovative probes called iBodies. Researchers will focus on metabolites with well-documented anti-anxiety properties from Piper methysticum or kava, a crop of the Pacific islands. They will validate their approach by identifying the brain receptors and hepatocyte enzymes that constitute primary targets of these kava metabolites. Long term, the iBodies methodology will offer the opportunity to develop non-opioid therapeutics of natural origin.

Call for proposal

H2020-MSCA-IF-2019
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Coordinator

USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I.
Address
Flemingovo Nam. 542/2
16610 Praha 6
Czechia

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Activity type
Research Organisations
EU contribution
€ 156 980,64