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Photoredox catalysis as a tool for the site-specific labelling of proteins

Project description

A new chemical diagnostic approach

The formation of 3-nitrotyrosine (3NT) is the result of tyrosine oxidation in proteins. In vivo, it serves as an indicator of oxidative damage and is encountered in diverse pathological conditions including Alzheimer's disease, heart disease and stroke. However, existing chemical strategies for detecting the presence of 3NT are limited by harsh chemical conditions and poor site selectivity. To address this, the EU-funded PhotoChemBio project proposes to use visible light to drive photoredox catalysis in order to identify this important residue within the proteome. The generated platform will facilitate disease diagnosis at an early stage as well as the development of new therapeutic strategies.

Objective

Photoredox catalysis (the use of visible-light to accelerate chemical reactions) has emerged as a uniquely valuable platform in organic chemistry, facilitating the use of native functionality to construct new C–C bonds. The key aim of this research is the unification of photoredox catalysis and bioconjugation to specifically target 3-nitrotyrosine (3NT) – a critical biomarker for the diagnosis of several diseases including Alzheimer's, heart disease, and stroke, in order to facilitate the rapid identification and mapping of this important residue within the proteome. Current chemical strategies to functionalize 3NT residues are hampered by harsh chemical conditions and poor site-selectivity; therefore, the development of a novel platform based upon the use of visible-light will have far-reaching implications in terms of identifying early-stages of disease and the development of new therapeutic strategies.

Fields of science (EuroSciVoc)

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Programme(s)

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Topic(s)

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Funding Scheme

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MSCA-IF-GF - Global Fellowships

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Call for proposal

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(opens in new window) H2020-MSCA-IF-2019

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Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 189 099,84
Address
TRINITY LANE THE OLD SCHOOLS
CB2 1TN CAMBRIDGE
United Kingdom

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 189 099,84

Partners (1)

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