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APC/C substrates: how are they disengaged from their non-degraded binding partners?

Project description

Insight into the molecular mechanism of cell division

During mitosis, sister chromatids of each chromosome are equally divided over two newly formed daughter cells. To safeguard genomic stability and ensure error-free division, the APC/C protein complex promotes the progression to anaphase by targeting cell cycle regulators for degradation. The scope of the EU-funded UbiBranch project is to clarify the underlying molecular mechanism by which APC/C functions. Using a multi-disciplinary approach that combines molecular biology, proteomics and in vivo cell biology, scientists will address the control of APC/C on its different substrates. The work aims to unveil novel targets with potential therapeutic value.

Call for proposal

H2020-MSCA-IF-2019
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Funding Scheme

MSCA-IF-EF-RI - RI – Reintegration panel

Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN
Address
Albinusdreef 2
2333 ZA Leiden
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 187 572,48