APC/C substrates: how are they disengaged from their non-degraded binding partners?

During mitosis, sister chromatids of each chromosome are equally divided over two newly formed daughter cells. To safeguard genomic stability and ensure error-free division, the APC/C protein complex promotes the progression to anaphase by targeting cell cycle regulators for degradation. The scope of the EU-funded UbiBranch project is to clarify the underlying molecular mechanism by which APC/C functions. Using a multi-disciplinary approach that combines molecular biology, proteomics and in vivo cell biology, scientists will address the control of APC/C on its different substrates. The work aims to unveil novel targets with potential therapeutic value.