Project description
An in vitro 3D skin model for assessing cosmetic chemicals
Per- and polyfluoroalkyl substances (PFAS) are man-made chemicals encountered at high levels in many products including cosmetics. Scientists of the EU-funded FluoroCosm project wish to determine the toxicity of these compounds following contact with the human skin. For this purpose, they will employ innovative 3D human tissue culture techniques to study dermal absorption and metabolism of PFAS. This skin equivalent approach has the potential to serve as an advanced model for investigating the implication of the skin in PFAS pharmacokinetics. More importantly, it will offer accurate risk assessment of these chemicals alongside information on their effect on human health.
Objective
FluoroCosm is a multidisciplinary project that combines advanced environmental analytical chemistry with innovative 3D human tissue culture techniques to study the dermal absorption of per- and polyfluoroalkyl substances (PFAS) from Cosmetic products. Recent studies detected PFAS compounds in various cosmetic products on the European market at high levels (up to 470 μg/g). The main hypothesis that FluoroCosm tests is that PFAS can be metabolized and absorbed through human skin, suggesting frequent contact with PFAS-containing cosmetics can lead to significant body burdens and thus adverse health effects.
While dermal contact with consumer products has been highlighted as a major pathway of human exposure to brominated flame retardants and was correlated with their levels in serum, no information are currently available on the dermal metabolism/absorption of PFAS, which hinders accurate risk assessment of these chemicals. Therefore, FluoroCosm aims to fill this major research gap by assessing human dermal metabolism/absorption of various PFAS present in Cosmetics, through real-life exposure scenarios.
This will be achieved using innovative in vitro 3D human skin equivalent cultures as alternatives to animal/human tissues. The results will be applied to develop an advanced pharmacokinetic model to evaluate the contribution of the dermal pathway to PFAS human body burdens and the potential toxic implications for such exposure.
Our vision is that improved understanding of various aspects of human dermal exposure to PFAS will provide for more accurate risk assessment studies. This will benefit public health and regulators by providing the necessary knowledge base to inform policies on correct measurements to limit human exposure to PFAS. FluoroCosm will also benefit scientists by delivering sustainable effective approaches to assessing human dermal exposure to current-use hazardous chemicals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences analytical chemistry
- medical and health sciences health sciences public health
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
B15 2TT Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.