Project description
Novel antibacterial metallic glass microfibers
The major cause of metal implants failure is infection due to bacterial biofilm formation on their surface. The EU-funded MAGIC project proposes the development of Zr-Cu-Ag metallic glasses that have intrinsic antibacterial properties without the need of additional coating. The development of this novel class of metals requires an understanding of their antibacterial mechanism. The project's main objective is to discover the underlying antibacterial mechanism of innovative Zr-Cu-Ag metallic glasses though a novel interdisciplinary approach combining materials engineering with advanced biological analysis of bacteria. The project aims to fabricate the best found Zr-Cu-Ag metallic glass in the form of microfibers as a proof-of-concept for the application of antibacterial metallic glasses in the medical industry.
Objective
The proposed training-through-research aims to develop novel antibacterial materials for medical devices based on Zr-Cu-Ag metallic glasses in the form of microfibers. The major cause of metal implants retrieval is infection due to bacterial biofilm formation on their surface. Many studies have been conducted on the development of antibacterial coating on metallic implants, but evidence has shown numerous drawbacks associated with coatings including their lack of durability. “MAGIC” project proposes the development of Zr-Cu-Ag metallic glasses with generic and intrinsic antibacterial properties which makes them capable of battling antibiotic resistance bacterial infection with no further required coating. Meaningful development of this novel class of intrinsic antibacterial metals requires a fundamental understanding of their antibacterial mechanism which to date is not well-understood. Therefore, “MAGIC” project fundamental ambition is to discover the underlying antibacterial mechanism of innovative Zr-Cu-Ag metallic glasses though a novel interdisciplinary approach, combing materials engineering knowledge of metallic glasses with advanced biological analysis of bacteria. On the engineering side, the main antibacterial contributors “chemical composition” and “surface energy” of Zr-Cu-Ag metallic glass will be modified and controlled; On the biological analysis side, bacterial genetic and metabolic response to these changes will be studied by coupling basic metabolic assays with next-generation sequencing and omics techniques. Furthermore, to facilitate the integration of antibacterial metallic glasses in the medical industry, “MAGIC” has an applied ambition to fabricate the best found Zr-Cu-Ag metallic glass (in terms of chemical composition and surface energy) in the form of microfibers for the very first time. Microfibers have higher surface areas and are easier to be formed into different shapes, offering added value to their applicability in industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- engineering and technology materials engineering coating and films
- medical and health sciences medical biotechnology implants
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
10129 Torino
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.