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Age-related arterial dysfunction and gut dysbiosis in mice and cetaceans

Project description

Strategies to prevent cardiovascular diseases: lessons from dolphins

Arterial dysfunction is one of the problems associated with ageing that can lead to cardiovascular disease (CVD), the number one cause of death in Europe. The EU-funded Arterial Aging project will investigate how age-related changes in the gut microbiome known to activate pro-oxidant and pro-inflammatory signalling pathways can modulate arterial function. Scientists will carry out analyses in experimental models to associate gut microbiota composition with vascular phenotypes. They will also explore if cetaceans, such as whales and dolphins, have a protective mechanism to prevent arterial dysfunction associated with diving. Results will potentially unveil a novel role of gut microbiota in vascular biology with important clinical consequences.

Objective

Cardiovascular disease (CVD) is the number one cause of death in Europe. Arterial dysfunction develops with aging making advancing age the primary risk factor for CVD. Advancing age can induce adverse changes in the gut microbiome, which in turn, can activate systemic pro-oxidant and pro-inflammatory signaling pathways with detrimental downstream consequences. One main objective of this project is to investigate the role of the gut microbiome in modulating arterial function with aging. To approach this objective, I will carry out two experimental studies: 1) mouse-to mouse transplant of gut microbiota to investigate if gut microbiota transfers vascular phenotypes. This experiment will show if gut microbiota modulates arterial function with aging, and will provide insight into the mechanisms involved. 2) Germ-free mice with microbiota samples from human subjects to determine the contribution of the human microbiome to a particular phenotype.
Cetaceans are long-lived mammals and excellent divers. They undergo constant cycles of tissue hypoxia-reoxygenation and shear stress caused by vascular adjustments while diving. In humans, these adjustments produce an elevation of oxidative stress and inflammation markers and impairment of the endothelial function. Thus, another main objective of this proposal is to explore if cetaceans, i.e. whales and dolphins, have developed an endothelium-protective mechanism to prevent arterial dysfunction with age and diving. To approach this objective I will study vascular function, circulating oxidative stress and inflammation markers, and gut microbiome of cetaceans of different ages in captivity as well as stranded animals.
The objectives to investigate the role of the gut microbiome in modulating arterial function with aging will be carried during the first two years in the outgoing phase. This knowledge will be transfer to the host institution for the study of vascular function and gut microbiome in cetaceans of different ages.

Coordinator

UNIVERSIDAD DE LAS PALMAS DE GRAN CANARIA
Net EU contribution
€ 245 732,16
Address
C/ Juan de Quesada 30
35001 Las Palmas De Gran Canaria
Spain

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Region
Canarias Canarias Gran Canaria
Activity type
Higher or Secondary Education Establishments
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Total cost
€ 245 732,16

Partners (1)