Instructing Immune System to Regenerate Musculoskeletal Tissues via Structurally Programmable Bio-Inks

Project Information

ImmunoBioInks

Grant agreement ID: 893099

DOI

10.3030/893099

Project closed

EC signature date 16 April 2020

Start date 1 July 2021

End date 30 June 2023

Funded under

EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 191 149,44

EU contribution

€ 191 149,44

191 149,44

Coordinated by

AO FORSCHUNGSINSTITUT DAVOS
Switzerland

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

EXPECT: A thermosensitive embedded bioprinting platform for guided spatial cell organization

Author(s): Athanasia Pylostomou, Jacek K. Wychowaniec, Riccardo Tognato, Sarah T. Egger, Gion U. Alig, Charlotte J.C. Edwards-Gayle, Fatemeh Safari, Jennifer R. Weiser, Dagnija Loca, Matteo D'Este, Tiziano Serra, Andrea J. Vernengo
Published in: Smart Materials in Medicine, Issue 6, 2026, Page(s) 347-367, ISSN 2590-1834
Publisher: Elsevier BV
DOI: 10.1016/j.smaim.2025.09.002

A continuum mechanical porous media model for vertebroplasty: Numerical simulations and experimental validation

Author(s): Zubin Trivedi, Dominic Gehweiler, Jacek K. Wychowaniec, Tim Ricken, Boyko Gueorguiev, Arndt Wagner & Oliver Röhrle
Published in: Biomechanics and Modeling in Mechanobiology, 2023, ISSN 1617-7959
Publisher: Springer Verlag
DOI: 10.1007/s10237-023-01715-4

Rheological Analysis and Evaluation of Measurement Techniques for Curing Poly(Methyl Methacrylate) Bone Cement in Vertebroplasty

Author(s): Zubin Trivedi, Jacek K. Wychowaniec, Dominic Gehweiler, Christoph M. Sprecher, Andreas Boger, Boyko Gueorguiev, Matteo D’Este, Tim Ricken, Oliver Röhrle
Published in: ACS Biomaterials Science & Engineering, Issue 10, 2025, Page(s) 4575-4586, ISSN 2373-9878
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsbiomaterials.4c00417

Effect of Tyrosine-Containing Self-Assembling β-Sheet Peptides on Macrophage Polarization and Inflammatory Response

Author(s): Jacek K. Wychowaniec, Ezgi Irem Bektas, Marcia Muerner, Jiranuwat Sapudom, Martin Šrejber, Marielle Airoldi, Roland Schmidt, Andrea J. Vernengo, Charlotte J. C. Edwards-Gayle, Paul Sean Tipay, Michal Otyepka, Jeremy Teo, David Eglin, Matteo D’Este
Published in: ACS Applied Materials & Interfaces, Issue 17, 2025, Page(s) 27740-27758, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.4c19900

Emerging Magnetic Fabrication Technologies Provide Controllable Hierarchically-Structured Biomaterials and Stimulus Response for Biomedical Applications

Author(s): Jacek K. Wychowaniec; Dermot F. Brougham
Published in: Advanced Science, Issue 21983844, 2022, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202202278

Effect of Steam Sterilisation on Physico-Chemical Properties of Antibacterial Covalently Cross-Linked Ε-Polylysine/Hyaluronic Acid Hydrogels

Author(s): Artemijs Sceglovs Jacek K. Wychowaniec Ingus Skadiņš Aigars Reinis Matteo D'Este Kristine Salma-Ancane
Published in: Carbohydrate Polymer Technologies and Applications, 2023, ISSN 2666-8939
Publisher: Elsevier
DOI: 10.2139/ssrn.4523054

Functional hydrogels as therapeutic tools for spinal cord injury: New perspectives on immunopharmacological interventions

Author(s): Ciara M. Walsh, Jacek K. Wychowaniec, Dermot F. Brougham, Dearbhaile Dooley Ciara M. Walsh and Jacek K. Wychowaniec contributed equally to this work.
Published in: Pharmacology & Therapeutics, 2021, Page(s) 108043, ISSN 0163-7258
Publisher: Pergamon Press
DOI: 10.1016/j.pharmthera.2021.108043

Preparation and Characterization of Photo-Cross-Linkable Methacrylated Silk Fibroin and Methacrylated Hyaluronic Acid Composite Hydrogels

Author(s): Jhaleh Amirian, Jacek K. Wychowaniec, Matteo D′Este, Andrea J. Vernengo, Anastasija Metlova, Antons Sizovs, Agnese Brangule, Dace Bandere
Published in: Biomacromolecules, Issue 25, 2025, Page(s) 7078-7097, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.4c00319

An In Vitro and Ex Vivo Analysis of the Potential of GelMA Hydrogels as a Therapeutic Platform for Preclinical Spinal Cord Injury

Author(s): Ciara M. Walsh, Jacek K. Wychowaniec, Louise Costello, Dermot F. Brougham, Dearbhaile Dooley
Published in: Advanced Healthcare Materials, 2023, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202300951

Thermoresponsive polymers for cell support: poloxamers as a case study of promise and challenge

Author(s): Shane Clerkin, Krutika Singh, Danielle Winning, Ivan Krupa, John Crean, Dermot F. Brougham, Jacek K. Wychowaniec
Published in: Journal of Materials Chemistry B, Issue 13, 2025, Page(s) 9351-9376, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d5tb00588d

Bone microphysiological models for biomedical research

Author(s): Francisco Verdugo-Avello, Jacek K. Wychowaniec, Carlos A. Villacis-Aguirre, Matteo D'Este, Jorge R. Toledo
Published in: Lab on a Chip, Issue 25, 2025, Page(s) 806-836, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4lc00762j

Effect of crosslinking strategy on the biological, antibacterial and physicochemical performance of hyaluronic acid and ɛ-polylysine based hydrogels

Author(s): K. Salma Ancane, A. Sceglovs, E. Tracuma, J. Wychowaniec, Kristine Aunina, A. Ramata-Stunda, V. Nikolajeva, D. Loca
Published in: International Journal of Biological Macromolecules, Issue Volume 208, 31 May 2022, 2022, Page(s) 995-1008, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2022.03.207

Alginate microbeads and hydrogels delivering meropenem and bacteriophages to treat Pseudomonas aeruginosa fracture-related infections

Author(s): Baixing Chen, Luis Ponce Benavente, Marco Chittò, Jacek K. Wychowaniec, Virginia Post, Matteo D'Este, Caroline Constant, Stephan Zeiter, Wenli Feng, Mercedes González Moreno, Andrej Trampuz, Jeroen Wagemans, Jolien Onsea , R. Geoff Richards, Rob Lavigne, T. Fintan Moriarty, Willem-Jan Metsemakers
Published in: Journal of Controlled Release, Issue Volume 364, December 2023, Pages 159-173, 2023, ISSN 1873-4995
Publisher: Elsevier
DOI: 10.1016/j.jconrel.2023.10.029

Charge Directed Selective Co‐Assembly of Ionic Complementary Peptide Binary Mixtures

Author(s): Abdulwahhab Khedr, Mohamed A. N. Soliman, Alfred Corrigan, Tarsem Sahota, Rachel Armitage, Natalie Allcock, Jeyapriya T. Jegadeesan, Mahetab H. Amer, Reem Alazragi, Zeeshan Ahmad, Jacek K. Wychowaniec, Mohamed A. Elsawy
Published in: Small, Issue 22, 2026, Page(s) e13140, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202513140

Hierarchical porous metal–organic gels and derived materials: from fundamentals to potential applications

Author(s): Jacek K. Wychowaniec, Haneesh Saini, Błażej Scheibe, Deepak P. Dubal, Andreas Schneemann and Kolleboyina Jayaramulu
Published in: Chemical Society Reviews, 2022, Page(s) 9068-9126, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2cs00585a

Versatile Potential of Photo-Cross-Linkable Silk Fibroin: Roadmap from Chemical Processing Toward Regenerative Medicine and Biofabrication Applications

Author(s): Amirina, Jhaleh; Wychowaniec, Jacek, K.; Zendehdel, Ehsan Amel; Sharma, Gaurav; Brangule, Agnese; Bandere, Dace
Published in: Biomacromolecules, Issue 1, 2023, ISSN 1526-4602
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.3c00098

Self-assembly of Tyrosine-containing Peptides into Injectable Hydrogels with Distinct Nanostructures is Key in Determining Inflammatory Response of Macrophages

Author(s): Jacek K. Wychowaniec, Ezgi Irem Bektas, Marcia Mürner, Jiranuwat Sapudom, Martin Šrejber, Marielle Airoldi, Roland Schmidt, Andrea J. Vernengo, Charlotte J.C. Edwards-Gayle, Paul Sean Tipay, Michal Otyepka, Jeremy Teo, David Eglin, Matteo D'Este
Published in: 2026
Publisher: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2024-bn5sm-v2

Harnessing Thermogel Actuation for Driving Directional Stromal Cell Communication and Migration into Columnar Arrays

Author(s): Andrea Vernengo, Athanasia Pylostomou, Jacek Wychowaniec, Riccardo Tognato, Sarah Egger, Gion Ursin, Charlotte Edwards-Gayle, Jennifer Weiser, Dagnija Loca, Matteo Deste, Tiziano Serra
Published in: 2025
Publisher: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-3827648/v1

Characterization of peptide-based nanomaterials

Author(s): C. J. C. Edwards-Gayle and J. Wychowaniec
Published in: Peptide Bionanomaterials: From Design to Application, 2023, ISBN 978-3-031-29360-3
Publisher: Springer
DOI: 10.1007/978-3-031-29360-3_8

Analysing the bone cement flow in the injection apparatus during vertebroplasty

Author(s): Zubin Trivedi, Dominic Gehweiler, Jacek K. Wychowaniec, Tim Ricken, Boyko Gueorguiev-Rüegg, Arndt Wagner, Oliver Röhrle
Published in: Proceedings in Applied Mathematics and Mechanics, 2023, ISSN 1617-7061
Publisher: Proceedings in Applied Mathematics and Mechanics
DOI: 10.1002/pamm.202200295

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