Kidney-resident regulatory T cells in health and disease
Patients suffering from chronic or end-stage renal disease often resort to kidney transplantation as a cure. Regulatory T cells (Tregs) have been proposed as a means of inducing tissue-specific tolerance as an alternative to systemic immune suppression following transplantation. At the same time, they protect from injury and promote tissue repair. However, it is yet unclear whether this effect is mediated by tissue-resident Tregs or those in circulation. The EU-funded Kidney-Treg project will characterise Tregs in the kidney using state-of-the-art molecular biology techniques and determine their impact on kidney physiology. The key objective is to explore the functions of these kidney-resident cells as novel therapeutic tools.