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Functional relevance of mitochondrial supercomplex assembly in myeloid cells

Project description

Targeting metabolism to regulate immune response

Myeloid cells are key immune players implicated in innate and adaptive immunity as well as tolerance. Regulating their activity is, therefore, of great therapeutic interest for the treatment of many diseases. Emerging evidence indicates that following an infection or tissue damage, myeloid cells adapt to mitochondrial functions such as metabolite production, ATP synthesis and reactive oxygen species (ROS) production. To understand how mitochondrial organisation is coupled to immune cell function, the EU-funded MY MITOCOMPLEX project is investigating the formation of the electron transport chain in macrophages and dendritic cells. Using state-of-the-art metabolomics and transcriptomics, the study has the potential to unveil novel targets for manipulating immune cell function.

Coordinator

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Net EU contribution
€ 172 932,48
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Spain

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Other funding
€ 0,00