Dissecting neuroinflammation in Parkinson's disease
Over one million people in Europe alone suffer from Parkinsonian disorders (PD), which lead to decreased motor activity. Accumulating evidence indicates that neuroinflammation is partly responsible for the observed PD pathology with IFNβ signalling playing an instrumental role in neuronal function. The EU-funded ParkIFNAR project aims to study the IFNβ pathway in PD, identify mutations in the IFNβ receptors (IFNARs) in PD patients and assess how these affect downstream signalling events. Collectively, the project's activities have the potential to identify pathway regulators that could be used to restore neuronal homeostasis and therefore serve as therapeutic targets in PD.
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