Studying the Negr1 interacting network in psychiatric and neurodevelopmental disorders
Compelling evidence indicates that most psychiatric and neurodevelopmental disorders are associated with aberrant neuronal connectivity. Most importantly, the neuronal growth regulator 1 (Negr1) is associated with neuronal connectivity and a number of diverse brain disorders. The EU-funded PSYNegrT project will investigate the hypothesis that the brain's Negr1 interacting-protein network is remodelled in psychiatric and neurodevelopmental disorders. The study will investigate the role of specific Negr1 complexes in diverse brain disorders and their possible exploration as drug targets. This project aims to produce the first exhaustive list of cerebral Negr1 interacting proteins in physiological conditions and to identify the protein–protein interactions involved in Negr1-mediated pathological aberrations.