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Unraveling the Molecular Changes that Drive the Repression of the Unfolded Protein Response with Ageing

Project description

Worms in the fight against ageing

The synthesis and folding of proteins are paramount to their function. Although organisms have evolved mechanisms for monitoring protein folding in specific organelles within cells, these decline with ageing. As a result, protein aggregates accumulate and cause age-related disorders such as Alzheimer's disease. Using the nematode Caenorhabditis elegans as a model, the EU-funded UCUPA project is investigating the unfolded protein response (UPR) protein quality control mechanism of the endoplasmic reticulum (ER) which declines with ageing. Using genome editing, scientists are evaluating different UPR signalling molecules which will shed light on the mechanisms of ageing. The project will also test novel interventions opening new therapeutic avenues for age-related disorders.


Net EU contribution
€ 212 933,76
Polaris House North Star Avenue
SN2 1FL Swindon
United Kingdom

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South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Swindon
Activity type
Research Organisations
Other funding
€ 212 933,76