Worms in the fight against ageing
The synthesis and folding of proteins are paramount to their function. Although organisms have evolved mechanisms for monitoring protein folding in specific organelles within cells, these decline with ageing. As a result, protein aggregates accumulate and cause age-related disorders such as Alzheimer's disease. Using the nematode Caenorhabditis elegans as a model, the EU-funded UCUPA project is investigating the unfolded protein response (UPR) protein quality control mechanism of the endoplasmic reticulum (ER) which declines with ageing. Using genome editing, scientists are evaluating different UPR signalling molecules which will shed light on the mechanisms of ageing. The project will also test novel interventions opening new therapeutic avenues for age-related disorders.
Fields of science
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- natural sciencesphysical sciencesopticsmicroscopy
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsprotein folding
- natural sciencesbiological sciencesmolecular biology