Project description
Novel imaging method for skin diseases
The diagnosis of skin and subcutaneous diseases takes place through dermoscopy and biopsy, which, however, are either not sensitive enough or very invasive and time-consuming. To address this problem, the EU-funded SkinOptima project proposes to develop a multi-modal optical method for imaging cutaneous blood vessels in a non-invasive manner. The approach is based on the fact that skin and subcutaneous diseases alter the cutaneous vasculature. Using this approach, scientists will be able to quantitatively analyse the vascular parameters of major skin diseases such as dermatitis and basal cell carcinoma and establish a link with their unique vascular patterns.
Objective
According the the Global Study of Diseases 2017, skin and subcutaneous diseases have increased rapidly in the past decade measured by the disability adjusted life years. However, there is still a lack of knowledge in many of these diseases, and the need for a novel method to study, diagnose and treat skin disease is ever-increasing. The current diagnostic tools, such as dermoscopy and biopsy, are either not sensitive enough or very invasive and time-consuming. Knowing that skin and subcutaneous diseases alter the cutaneous vasculature, SkinOptima proposes to use a multi-modal optical imaging method to extract the complete human cutaneous blood vessels in a non-invasive and in vivo manner. Then, the blood vessel network will be quantified in different perspectives. Using quantitative analysis of the vascular parameters, a link between three major skin diseases and their unique vascular patterns can be established. A lesion area determination algorithm will also be developed to help the dermatologists prepare skin cancer removal surgeries and monitor the treatment efficacy. This multi-modal approach involves two optical imaging modalities - optical coherence tomography (OCT) and photoacoustic tomography (PAT). OCT alone can extract tissue morphology for about 1 mm in skin. A functional extension of OCT, called OCT angiography (OCTA) is capable to extract the micro-vessels in the first millimeter in skin. PAT, on the other hand, can image skin blood vessels with a coarser resolution from 1 mm down to 5 mm below the skin surface. An imaging probe will be designed to combine these two modalities for patient imaging. To develop all the vessel extraction and vessel quantification algorithms, several types of skin phantoms will be 3D printed. In the end, about 150 patients will be imaged by the multi-modal system and the link between vasculature and diseases such as basal cell carcinoma, squamous cell carcinoma and dermatitis will be established.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- medical and health sciences clinical medicine oncology skin cancer squamous cell carcinoma
- medical and health sciences clinical medicine oncology skin cancer basal cells
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1090 WIEN
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.