Project description
Novel non-invasive ventilation improves precision of radiological tumor treatment
For treating cancer, radiotherapy targets tumours as accurately as possible, while avoiding damage to surrounding healthy tissue. The greatest challenge is movement caused by the patient breathing during treatment. To guarantee complete tumour irradiation, the tumour and an additional margin of healthy tissue are irradiated. Clinicians are constantly striving to reduce this margin of healthy tissue. The goal of the EU-funded MV for radiotherapy project is to introduce clinically the use of non-invasive mechanical ventilators to facilitate radiotherapy. The ventilator techniques were invented by the project partners and showed great promise in proof-of-concept trials on breast cancer patients. The techniques can safely prolong breath-hold duration in patients beyond five minutes, thereby reducing and regularising breathing movements and improving radiotherapy targeting.
Objective
One of the greatest challenges for modern radiotherapy is ventilation causing motion of tumours and surrounding healthy structures. Technically, modern radiation delivery systems enable in principle very accurate radiation targeting of the tumour and avoiding radiation damage to healthy tissue. However, to deliver sufficient dose to a continuously and irregularly moving tumour, it is necessary to irradiate the tumour with a large margin. Currently such a large margin means irradiating a volume of healthy tissue that is about equal to that of the tumour itself. The healthy tissue damage is itself problematic. But it also prohibits further raising the radiation dose to the tumour to enhance the probability of tumour destruction and thus patient survival.
I have invented the use of non-invasive mechanical ventilators to revolutionise radiotherapy delivery, by prolonging breath-hold duration beyond 5 minutes and by reducing and regularising breathing movements. I have demonstrated this works with breast cancer patients. To support its clinical adoption it is now necessary to train other staff to use mechanical ventilation, demonstrate it works with other cancer patient groups, measure the reductions in internal movement of tumours and healthy structures, show how these would produce superior treatment plans and that all this works in another European hospital. My career goal is for me to use the evidence derived from the fellowship to fund the introduction of non-invasive mechanical ventilators first back in our own department (Birmingham, UK), then for me to lead a multi-centre evaluation trial across Europe and finally to lead its introduction into radiotherapy practice throughout Europe.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1105AZ Amsterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.