Improvement of tumour-targeting specificity and treatment initialisation
Prompt cancer diagnosis and treatment initialisation are closely linked to disease outcome. The EU-funded SPOT project is developing an innovative approach for cancer imaging and treatment that exploits the combinatorial use of small antibody fragments and nanoparticles. The small antibody fragments, which exhibit highly specific targeting capacities and are capable of deep tissue penetration, will serve as guides for bioimaging and drug-delivering nanoparticles. Click reactions between moieties attached to small antibody fragments and nanoparticles ensure the specific visualisation of tumor tissue as well as delivery of nanoparticle payload at the tumour site. The SPOT approach is expected to overcome the limitations associated with the direct conjugation of drugs, imaging probes or drug-delivering nanoparticles to antibodies, offering an advanced strategy for tumour imaging and treatment. The approach also intents to achieve a crucial time gain between diagnosis and treatment initialisation.
Call for proposal
See other projects for this call