Immunological mechanisms of post-stroke neurovascular recovery
Improvements in the treatment and prevention of ischemic stroke have improved survival rates, but an increased number of patients have to live with chronic post-stroke conditions. Recovery after stroke correlates with cerebral vascular function; therefore, patients with vascular reactivity dysfunction exhibit significant functional impairment. On the other hand, inflammation in autoimmune and infectious diseases also results in dysfunction of cerebral blood flow regulation. The goal of the EU-funded VasoRecovery project is to identify the impact of cerebral, neuroinflammatory and systemic innate immune responses to vascular dysfunction after experimental stroke. The research will specifically target immune cell populations, analyse chronic functional outcomes after stroke and perform in vivo multimodal imaging.
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