Project description
Immunological mechanisms of post-stroke neurovascular recovery
Improvements in the treatment and prevention of ischemic stroke have improved survival rates, but an increased number of patients have to live with chronic post-stroke conditions. Recovery after stroke correlates with cerebral vascular function; therefore, patients with vascular reactivity dysfunction exhibit significant functional impairment. On the other hand, inflammation in autoimmune and infectious diseases also results in dysfunction of cerebral blood flow regulation. The goal of the EU-funded VasoRecovery project is to identify the impact of cerebral, neuroinflammatory and systemic innate immune responses to vascular dysfunction after experimental stroke. The research will specifically target immune cell populations, analyse chronic functional outcomes after stroke and perform in vivo multimodal imaging.
Objective
Ischemic stroke is one of the most common causes of disability and death in the EU. Improvements in treatment and prevention of ischemic stroke have reduced this burden, but consequently, patients living with chronic post-stroke conditions are increasing in number. Addressing this emergent public health problem will require novel rehabilitation interventions at the clinical level. Recovery after stroke correlates closely with cerebral vascular function, such that patients with dysfunction of vascular reactivity exhibit significant functional impairment. On the other side, inflammation in autoimmune and infectious diseases has been demonstrated to also result in dysfunction of cerebral blood flow regulation. However, a potential mechanistic link between the post-stroke inflammatory response and chronically impaired vascular dysfunction after stroke has yet not been studied in detail. Therefore, the goal of this project is to identify the impact of cerebral, neuroinflammatory and systemic innate immune responses to vascular dysfunction after experimental stroke.
To achieve this goal, under the supervision of Dr. Arthur Liesz at the Institute for Stroke and Dementia Research, I will learn to specifically target immune cell populations, analyze chronic functional outcomes after stroke and gain expertise in performing in vivo multimodal imaging. Dr. Liesz runs an interdisciplinary highly collaborative research program within the conceptual framework of stroke-immunology. I will be able to contribute my previously acquired expertise in neurovascular function and in vivo vascular imaging for the success of this project. The Marie Sklodowska-Curie individual fellowship (MSC IF) will allow me to obtain the required methodological knowledge, access to critical infrastructure and collaboration partners in order to achieve this interdisciplinary and ambitious objective.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine neurology dementia
- medical and health sciences basic medicine neurology stroke
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.