Descripción del proyecto
Mecanismos inmunológicos de la recuperación neurovascular posictus
Las mejoras en el tratamiento y la prevención del ictus isquémico han mejorado las tasas de supervivencia, pero un mayor número de pacientes debe vivir con afecciones posictus crónicas. La recuperación posictus está relacionada con la función cerebrovascular; por tanto, los pacientes con disfunción de la reactividad vascular presentan un deterioro funcional significativo. Por otra parte, la inflamación de las enfermedades autoinmunes e infecciosas también conlleva la disfunción de la regulación del flujo sanguíneo del encéfalo. El objetivo del proyecto VasoRecovery, financiado con fondos europeos, es la identificación del impacto de las respuestas encefálica, neuroinflamatoria y del sistema inmunitario innato a la disfunción vascular tras un ictus experimental. La investigación se centrará específicamente en poblaciones de células inmunitarias, analizará los resultados funcionales crónicos posictus y realizará imagenología multimodal «in vivo».
Objetivo
Ischemic stroke is one of the most common causes of disability and death in the EU. Improvements in treatment and prevention of ischemic stroke have reduced this burden, but consequently, patients living with chronic post-stroke conditions are increasing in number. Addressing this emergent public health problem will require novel rehabilitation interventions at the clinical level. Recovery after stroke correlates closely with cerebral vascular function, such that patients with dysfunction of vascular reactivity exhibit significant functional impairment. On the other side, inflammation in autoimmune and infectious diseases has been demonstrated to also result in dysfunction of cerebral blood flow regulation. However, a potential mechanistic link between the post-stroke inflammatory response and chronically impaired vascular dysfunction after stroke has yet not been studied in detail. Therefore, the goal of this project is to identify the impact of cerebral, neuroinflammatory and systemic innate immune responses to vascular dysfunction after experimental stroke.
To achieve this goal, under the supervision of Dr. Arthur Liesz at the Institute for Stroke and Dementia Research, I will learn to specifically target immune cell populations, analyze chronic functional outcomes after stroke and gain expertise in performing in vivo multimodal imaging. Dr. Liesz runs an interdisciplinary highly collaborative research program within the conceptual framework of stroke-immunology. I will be able to contribute my previously acquired expertise in neurovascular function and in vivo vascular imaging for the success of this project. The Marie Sklodowska-Curie individual fellowship (MSC IF) will allow me to obtain the required methodological knowledge, access to critical infrastructure and collaboration partners in order to achieve this interdisciplinary and ambitious objective.
Ámbito científico
Programa(s)
Régimen de financiación
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinador
80539 Muenchen
Alemania