Project description
An antimicrobial catheter
Catheter-associated infections are caused by bacterial biofilms and require prolonged and extensive use of antibiotics, leading to the emergence of antimicrobial-resistant strains that are difficult to treat. In answer to this, scientists of the EU-funded PHOTO-IASIS project propose to develop novel catheters featuring an antimicrobial nanocoating that exhibits anti-biofilm properties. The coating consists of light-activated material that destroys the biofilm upon visible light irradiation delivered on the catheter surface through an optical fibre in the catheter opening. With a simple push of a button, this innovative design will tackle catheter-associated infections and minimise antimicrobial resistance in the hospital setting.
Objective
Catheter-associated infections are characterized by the formation of a bacterial biofilm on their surface and are a major clinical problem today with huge socioeconomic implications. As a result, apart from longer hospital admissions that dramatically increase healthcare costs, in order to fight these infections increased antibiotic drug doses are used. This approach places selective pressure on pathogens and, especially in nosocomial settings, facilitates the emergence of antimicrobial resistant bacteria that are more difficult, if at all possible, to treat. In fact, catheter-associated infections by antimicrobial resistant bacteria are potentially lethal, especially in patients with compromised immune system (cancer, HIV patients). So, there is an urgent societal and clinical need to reduce such infections. The target of this project is to re-engineer catheters that exhibit anti-biofilm properties due to the presence of an antimicrobial nanocoating. This coating will consist of a photo-active material that destroys the biofilm upon visible light irradiation. The light will be delivered on the catheter surface by an optical fiber through the catheter opening. This will enable biofilm destruction with a simple push of a button. The developed catheter here will revolutionize this field by reducing such catheter-associated infections, minimizing the emergence of drug resistant bacteria and improving the public health worldwide. The supervisor’s unique expertise in nanomaterial synthesis using flame spray pyrolysis (FSP), and in applying the resulting nanoparticles to specific biomedical applications combined with that of the applicant’s in nanoparticles and photocatalysis reassures a mutual benefit between the applicant and the host institute and enhances the feasibility of this proposal.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.