Project description DEENESFRITPL Genomic mechanisms in organism evolution Phenotype changes occur during the transition of some organisms from the surface to the subterranean environment. These include loss of eyes and skin pigmentation and increase of non-visual sensory organs. The olm (Proteus anguinus) is listed as a vulnerable species and represents a famous example of convergent evolution at this transition. The EU-funded GENEVOLCAV project will use the olm as a model organism to investigate and explain the genomic mechanisms involved in this transition. The project will reconstruct the number of independent transitions from the surface to caves across all olm lineages, generate a full chromosome-level assembly of the olm’s genome, detect the genetic and selective mechanisms, and reconstruct the demographic history of olm lineages. Show the project objective Hide the project objective Objective Understanding the causes of major changes of form and function of organisms is one of the big goals of evolutionary biology. Dramatic phenotypic changes happen at the transition from the surface to a subterranean life. They involve the loss of eyes and skin pigmentation, and augmentation of non-visual sensory organs. In this project I will investigate the genetic mechanisms involved in this transition, using the olm (Proteus anguinus), the largest obligate cave inhabitant, as a model organism. The olm is famous for its peculiar appearance and as a European flagship species of conservation priority. Underscoring its importance, sir David Attenborough listed it as one of ten species he would take on his personal ark to save it from extinction. The olm represents a famous example of convergent evolution at the transition from surface to caves, as already noted by Charles Darwin in his 'On the origin of species'. My overarching goal is to elucidate the genomic mechanisms involved in this transition. The specific objectives of this project are to i) reconstruct the number of independent transitions from surface to caves across all olm lineages, ii) produce a full chromosome-level assembly of the olm's genome, iii) identify the genetic and selective mechanisms associated with this transition, and iv) reconstruct the demographic history of olm lineages. This research will be made possible by combining the expertise of world-leading institutions in cave biology (University of Ljubljana) and sequencing technology (BGI- Research). Using this expertise and knowledge, I will answer a long-lasting question about the evolutionary mechanisms that drive the loss of characters. In addition, my work will contribute to the largest genome assembled for any animal species. The identification of independent evolutionary lineages will help setting urgently needed international conservation priorities for olms. Fields of science natural sciencesbiological sciencesevolutionary biologynatural sciencesbiological sciencesgeneticsgenomes Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2019 - Individual Fellowships Call for proposal H2020-MSCA-IF-2019 See other projects for this call Funding Scheme MSCA-IF-GF - Global Fellowships Coordinator UNIVERZA V LJUBLJANI Net EU contribution € 231 619,20 Address Kongresni trg 12 1000 Ljubljana Slovenia See on map Region Slovenija Zahodna Slovenija Osrednjeslovenska Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. BGI SHENZHEN LIFE SCIENCE RESEARCH INSTITUTION China Net EU contribution € 0,00 Address Building 11, beishan industrial zone yantian district 518083 Shenzhen See on map Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 156 599,04
