Project description
Novel mathematical analyses extract the atomic constituents of organic molecules
Atomic force microscopy (AFM) is a type of high-resolution scanning probe microscopy that creates a 3D topographic image of almost any type of surface by scanning a sharp cantilever tip over it. Non-contact AFM (nc-AFM) is similar but, as its name suggests, does not touch the surface, providing important benefits for biological sample preparations. Over the last couple of decades, it has provided important information about force interactions in biological materials as well as mechanical response measurements and supplied structural information about organic molecules. However, its resolution suffers relative to AFM and it is not possible to identify the individual atoms in a molecule. The EU-funded EIM project is developing spectral analysis algorithms that will enable extracting elemental identities from the signal obtained with nc-AFM. The technique will open the door to detailed atomic-level characterisation of molecules relevant to biotechnology, pharmaceutical development and environmental analyses using nc-AFM.
Objective
Molecular structure determination is vital for biochemistry, life science, and drug industry. A complete determination of the molecular structure requires both the structural skeleton and atoms therein to be identified. Non-contact Atomic Force Microscopy provided a method to image the real-space structural skeleton of planar organic molecule, however, the chemical identities of each atom that comprise the molecule are yet to be determined. In this proposal, I systematically analyze the physical principle for elemental identification in single molecules and propose a practical method to identify each atom using point spectrum with non-contact atomic force microscope.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- natural sciences physical sciences optics microscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
02150 Espoo
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.