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Cerebellar Rhythmic Entrainment with Transcranial Magnetic Stimulation: A new approach for the study of cerebellar connections with the cortex.

Project description

Insight into brain connections

The nervous system allows us to adapt our motor system to rapid environmental changes. This takes place through the exchange of information at specific anatomical connections between the cerebellum and the motor cortex in the brain. Scientists of the EU-funded cRETMS project aim to shed light on the dynamics of this connection, which is poorly understood. Using a range of state-of-the-art methodologies, they will study the anatomical and effective connectivity between the cerebellum and the motor cortex. The project's results will not only provide a mechanistic understanding of brain connectivity but will also contribute to the design of new interventions for enhancing human motor performance.

Objective

Adaptation to rapidly changing environmental demands is oneThe adaptation to rapid environmental changes represents one of the most important features of the nervous system. This process is regulated by the influence of the cerebellar output over the motor cortex (M1). Information exchange between the cerebellum and M1 is achieved through rich anatomical connections, and is essential for efficient motor adaptation. However, a macro-scale understanding of the dynamics of this connectom is still poorly understood. The originality of this project is to combine, for the first time, cerebellar rhythmic transcranial magnetic stimulation (rTMS), online electroencephalography (EEG) recordings, and offline diffusion magnetic resonance imaging (dMRI), for the study of cerebello-to-M1 connections. Specifically, cRETMS is articulated in two work-packages (WPs). WP1 will pave the technical ground by probing the hypothesis that cerebellar β-oscillations are physiologically relevant in terms of cerebello-to-M1 anatomical and effective connectivity. WP2 will use the technical proofs of concept coming from WP1 to test the importance of cerebellar β-frequency in the adaptation of motor movements, with the aim of enhancing human motor performance by means of rTMS. The present action may lead to a breakthrough into our mechanistic understanding of cerebellar-to-M1 functional connectivity, which in turn may inform interventions for the manipulation of brain oscillations subtending normal and impaired motor functions. The training provided by my supervisors will be essential to reach these goals. Through them and the excellency of the host institution, this fellowship will give me the opportunity to learn how to analyse diffusion magnetic resonance imaging (dMRI) data, and how to integrate structural and dynamic information coming from the brain. This will undoubtedly increase my chances to further advance my career, deepening my scientific expertise to become an independent researcher.

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Coordinator

INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
Net EU contribution
€ 184 707,84
Address
Boulevard de l'hopital 47
75013 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
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Other funding
€ 0,00