Project description
Insight into brain connections
The nervous system allows us to adapt our motor system to rapid environmental changes. This takes place through the exchange of information at specific anatomical connections between the cerebellum and the motor cortex in the brain. Scientists of the EU-funded cRETMS project aim to shed light on the dynamics of this connection, which is poorly understood. Using a range of state-of-the-art methodologies, they will study the anatomical and effective connectivity between the cerebellum and the motor cortex. The project's results will not only provide a mechanistic understanding of brain connectivity but will also contribute to the design of new interventions for enhancing human motor performance.
Objective
Adaptation to rapidly changing environmental demands is oneThe adaptation to rapid environmental changes represents one of the most important features of the nervous system. This process is regulated by the influence of the cerebellar output over the motor cortex (M1). Information exchange between the cerebellum and M1 is achieved through rich anatomical connections, and is essential for efficient motor adaptation. However, a macro-scale understanding of the dynamics of this connectom is still poorly understood. The originality of this project is to combine, for the first time, cerebellar rhythmic transcranial magnetic stimulation (rTMS), online electroencephalography (EEG) recordings, and offline diffusion magnetic resonance imaging (dMRI), for the study of cerebello-to-M1 connections. Specifically, cRETMS is articulated in two work-packages (WPs). WP1 will pave the technical ground by probing the hypothesis that cerebellar β-oscillations are physiologically relevant in terms of cerebello-to-M1 anatomical and effective connectivity. WP2 will use the technical proofs of concept coming from WP1 to test the importance of cerebellar β-frequency in the adaptation of motor movements, with the aim of enhancing human motor performance by means of rTMS. The present action may lead to a breakthrough into our mechanistic understanding of cerebellar-to-M1 functional connectivity, which in turn may inform interventions for the manipulation of brain oscillations subtending normal and impaired motor functions. The training provided by my supervisors will be essential to reach these goals. Through them and the excellency of the host institution, this fellowship will give me the opportunity to learn how to analyse diffusion magnetic resonance imaging (dMRI) data, and how to integrate structural and dynamic information coming from the brain. This will undoubtedly increase my chances to further advance my career, deepening my scientific expertise to become an independent researcher.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75013 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.