Project description DEENESFRITPL Making sense of the vast expanse between brain cells Understanding the human brain is one of the biggest scientific challenges. Until now, one aspect that that has been sparsely researched is the extracellular space (ES) of the brain. The ES of the brain is important in the field of neuropharmacology because it is key to the successful delivery of drugs. Also, the importance of the metabolite clearance activity of the ES has led to considering its role in neurodegenerative diseases. To help in the understanding of the ES, the Hippocampus Extracellular Space Simulator Project (HESSP) is going to be executed. The EU-funded HESSP project goal is to develop a software that simulates the diffusion process of endogenous and exogenous substances in the ES of the mouse’s hippocampus. Show the project objective Hide the project objective Objective Understanding the human brain is one of the biggest scientific challenges of the 21st century, and this endeavor has led the European Union to launch the Human Brain Project (HBP) as a FET flagship project. However, even a flagship project such as the HBP cannot study all aspects of the human brain. One aspect that is not covered by the HBP is the extracellular space (ES). The ES of the brain is important in the field of neuropharmacology because it is key to the successful delivery of drugs to the neurons. Also, the importance of the metabolite clearance activity of the ES has led to proposing that a dysfunction of this process plays a role in neurodegenerative diseases. However, to the best of the eligible researcher’s knowledge, no initiative exists to create an ES simulation software that improves the research. To address this lack of simulation software, this proposal presents the Hippocampus Extracellular Space Simulator Project (HESSP). The HESSP’s goal is to develop a simulation software for how substances released by neurons and chemical substances that pass the blood-brain barrier diffuse through the ES. Specifically, the HESSP will create a software that simulates the diffusion process in the ES of the mouse’s hippocampus. The HESSP is an interdisciplinary project that involves computer science, neuroscience and pharmacology, and it addresses the challenge of developing a software architecture to simulate a diffusion process highly complex due to its number of elements formed. The hippocampus was chosen because it is a well-known structure, the results can be tested, and it is the earliest brain structure affected in Alzheimer’s disease (AD). The HESSP will open a frontier line of research at the host university in collaboration with leading scientists in ES and neurodegenerative diseases. Additionally, the eligible researcher will acquire frontier knowledge in the simulation of complex biophysical processes and in neuroscience. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologydementiaalzheimermedical and health sciencesbasic medicinepharmacology and pharmacynatural sciencescomputer and information sciencessoftwaresoftware applicationssimulation software Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2019 - Individual Fellowships Call for proposal H2020-MSCA-IF-2019 See other projects for this call Funding Scheme MSCA-IF-GF - Global Fellowships Coordinator UNIVERSIDAD DE SALAMANCA Net EU contribution € 245 732,16 Address Calle patio de escuelas 1 37008 Salamanca Spain See on map Region Centro (ES) Castilla y León Salamanca Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK United States Net EU contribution € 0,00 Address State street 35 12201 Albany ny See on map Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 165 265,92
