Encoding of episodic memory in hippocampal neurons
During brain development, the novel context is rapidly integrated and transformed into new memory, with early-life experiences encoded in the hippocampus, a brain region central to memory formation and recall. Recent studies have demonstrated that a subset of hippocampal neurons show more rigid, stable activation patterns across the behavioural domain, while others are more plastic. The EU-funded RigidPlasticNeurons project proposes to study the ensemble code in the developing mouse hippocampus using a combination of techniques paired with a behavioural navigation assay to measure in vivo the activities of neurons, with a focus on the functional properties of rigid and plastic neurons during development.
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