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Targeting the cancer stem cell (CSC) metabolism with designed, reactive metal complexes

Project description

Novel metal compounds as anti-cancer agents

A G-quadruplex is a four-stranded nucleic acid secondary structure formed in G nucleotide-rich regions of the DNA or RNA. Emerging evidence implicates these structures in cancer growth and progression. With this in mind, the EU-funded antiCSC project proposes to develop metal-based compounds that have the capacity to interact with accessible guanines present in adjacent positions to these self-assembled structures, and thereby alter their conformation and function. Preliminary results indicate that these compounds suppress the stemness of cancer stem cells by interfering with mitochondrial respiration. The antiCSC proposal will determine the mechanism underlying the action of these metal compounds and exploit their potential as novel anti-cancer agents.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

ERC-2019-PoC
See other projects for this call

Funding Scheme

ERC-POC-LS - ERC Proof of Concept Lump Sum Pilot

Host institution

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Address
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 130 000

Beneficiaries (2)

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain
EU contribution
€ 130 000
Address
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD AUTONOMA DE MADRID
Spain
EU contribution
€ 20 000
Address
Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid
Activity type
Higher or Secondary Education Establishments