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Bidirectional flow filter: microfluidic device for separation of biomolecules

Project description

Extraction of molecules and particles from sub-microlitre samples

Life science and biomedical applications, including point-of-care diagnostics and forensic analysis, involve analysis of extremely small samples. Despite the availability of large arsenals of sample preparation methods, current approaches are often not suitable for volumes below the microlitre range. The EU-funded BiFlowFilter proof-of-concept project aims to develop a technology for rapid and high-purity extraction of molecules and particles from sub-microlitre volumes. The main objectives of the project include technical optimisation and validation of the technology as well as the establishment of a solid foundation for commercialisation. The novel separation technology will be uniquely positioned in the market of sample preparations and has the potential to be an important component in the future of point-of-care diagnostics and personalised medicine.

Objective

The analysis of extremely small samples is boosting the field of life and medical science, from basic research on single-cell systems, through point-of-care diagnostics, to forensic analysis. Despite great advances made on analytical techniques such as digital immunoassay, nanopore detection and next-generation sequencing, little progress has been made on low-volume sample preparation technologies, which are key for the success of such analytical techniques. To date, despite the availability of a large arsenal of sample preparation methods, current approaches are simply not suitable for volumes below the microliter range.
In this proposed ERC proof-of-concept project we aim to develop a device and method for rapid and high-purity extraction of molecules and particles from sub-microliter volumes. The main objectives of this project cover the technical optimization and validation of the technology as well as the establishment of a solid foundation for its commercialization.
We believe that this separation technology will be uniquely positioned in the sample preparation market and has the potential to be an important component in the future of point-of-care diagnostics and personalized medicine.

Host institution

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Net EU contribution
€ 150 000,00
Address
SENATE BUILDING TECHNION CITY
32000 Haifa
Israel

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Activity type
Higher or Secondary Education Establishments
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Total cost
No data

Beneficiaries (1)