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ADDovenom: Novel Snakebite Therapy Platform of Unparalleled Efficacy, Safety and Affordability

Project description

Proteomics, transcriptomics and bioinformatics for development of novel snakebite therapy

Snakebites can be life-threatening when venom toxins are injected and enter the bloodstream. In areas where immediate access to specialised medical care is limited, bites by venomous snakes cause many thousands of deaths each year. The EU-funded ADDovenom project will use an innovative platform enabling generation of new snakebite treatment, based on a new disruptive protein-based nanoscaffold called ADDomer – a megadalton-sized, thermostable synthetic virus-like particle with 60 high-affinity binding sites to neutralise and eliminate venom toxins from the bloodstream. ADDovenom combines pioneering proteomics, transcriptomics and bioinformatics focusing on snake toxins provoking the most challenging syndromes like haemorrhage and paralysis. The aim is to develop first-in-class neutralising superbinders for snakebite therapy of unprecedented efficacy against the most prevalent Sub-Saharan snakes.

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
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Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITY OF BRISTOL
Address
Beacon House Queens Road
BS8 1QU Bristol
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 997 063,75

Participants (4)

UNIVERSITE DE LIEGE
Belgium
EU contribution
€ 621 250
Address
Place Du 20 Aout 7
4000 Liege
Activity type
Higher or Secondary Education Establishments
LIVERPOOL SCHOOL OF TROPICAL MEDICINE
United Kingdom
EU contribution
€ 949 637,50
Address
Pembroke Place
L35QA Liverpool
Activity type
Higher or Secondary Education Establishments
UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 601 375
Address
Boulevard Charles Livon 58
13284 Marseille
Activity type
Higher or Secondary Education Establishments
INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA
Portugal
EU contribution
€ 506 232,50
Address
Avenida Da Republica Quinta Do Marques
2781-901 Oeiras
Activity type
Research Organisations