ADDovenom: Novel Snakebite Therapy Platform of Unparalleled Efficacy, Safety and Affordability

Project Information

ADDovenom

Grant agreement ID: 899670

DOI 10.3030/899670

EC signature date 26 May 2020

Start date 1 October 2020

End date 31 March 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 3 675 558,75

EU contribution € 3 675 558,75

Coordinated by

UNIVERSITY OF BRISTOL
United Kingdom

Deliverables

Documents, reports (8)

List of protein / peptide components for 8 African snake venoms and their relative abundance identified by MS

List of protein peptide components for 8 African snake venoms and their relative abundance identified by MS

White paper 1
List of sequences, PTMs, disulphide bridges and isoelectric points of the venom components (2 snakes)

List of sequences PTMs disulphide bridges and isoelectric points of the venom components 2 snakes

Validated protocols for the production of ADDobodies in high-throughput and milligram amounts

Validated protocols for the production of ADDobodies in highthroughput and milligram amounts

Determination of venom toxicity (LD50) for each snake species

Determination of venom toxicity LD50 for each snake species

List of protein / peptide components for 2 African snake venoms and their relative abundance identified by MS

List of protein peptide components for 2 African snake venoms and their relative abundance identified by MS

Validated protocols for the production of toxins/ epitope strings

Validated protocols for the production of toxins epitope strings

List of identified toxins and their predicted pharmacological activity in the venoms (2 snakes)

List of identified toxins and their predicted pharmacological activity in the venoms 2 snakes

Websites, patent fillings, videos etc. (1)

First version of the website

Open Research Data Pilot (1)

Data management plan

Publications

Peer reviewed articles (5)

Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition

Author(s): Stefanie K. Menzies; Charlotte A. Dawson; Edouard Crittenden; Rebecca J. Edge; Steven R. Hall; Jaffer Alsolaiss; Mark C. Wilkinson; Nicholas R. Casewell; Robert A. Harrison; Stuart Ainsworth
Published in: Scientific Reports, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-13376-x

Engineering the ADDobody protein scaffold for generation of high-avidity ADDomer super-binders

Author(s): Dora Buzas, Huan Sun, Christine Toelzer, Sathish K. N. Yadav, Ufuk Borucu, Gunjan Gautam, Kapil Gupta, Josh Bufton, Julien Capin, Richard B. Sessions, Frederic Garzoni, Imre Berger, Christiane Schaffitzel
Published in: Structure, 2023, ISSN 0969-2126
Publisher: Cell Press
DOI: 10.1101/2023.09.09.556966

Next-Generation Sequencing for Venomics: Application of Multi-Enzymatic Limited Digestion for Inventorying the Snake Venom Arsenal

Author(s): Fernanda Gobbi Amorim, Damien Redureau, Thomas Crasset, Lou Freuville, Dominique Baiwir, Stefanie K. Menzies, Nicholas R. Casewell, Loïc Quinton
Published in: Toxins, Issue 15(6), 2023, Page(s) 357, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins15060357

In vitro generated antibodies guide thermostable ADDomer nanoparticle design for nasal vaccination and passive immunization against SARS-CoV-2

Author(s): Dora Buzas, Adrian H Bunzel, Oskar Staufer, Emily J Milodowski, Grace L Edmunds, Joshua C Bufton, Beatriz V Vidana Mateo, Sathish K N Yadav, Kapil Gupta, Charlotte Fletcher, Maia K Williamson, Alexandra Harrison, Ufuk Borucu, Julien Capin, Ore Francis, Georgia Balchin, Sophie Hall, Mirella V Vega, Fabien Durbesson, Srikanth Lingappa, Renaud Vincentelli, Joe Roe, Linda Wooldridge, Rachel Burt, Ross
Published in: Antibody Therapeutics, Issue tbad024, 2023, ISSN 2516-4236
Publisher: Oxford Academic
DOI: 10.1093/abt/tbad024

ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming

Author(s): Stefanie K. Menzies, Raquel A. Garcia, Fernanda Gobbi Amorim, Iara Aimê Cardoso,Camille Abada, Thomas Crasset, Rebecca J. Edge, Sophie Hall, Damien Redureau, Richard Stenner, Johara Stringari, António Roldão, Paula M.vAlves, Robert A. Harrison, Renaud Vincentelli, Huan Sun, Imre Berger, Loïc Quinton, Nicholas R. Casewell, Christiane Schaffitzel
Published in: Toxins, Issue 15(12), 2023, Page(s) 673, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins15120673