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Precisely Patterned Nanofibers for High Performance Bioseparations

Project description

Scalable biotechnology for high performance bioseparation processes

Bioseparation is a critical step in biopharmaceutical manufacturing. It employs polymeric adsorbents decorated with affinity ligands to increase the selective capture of target biological products. The EU-funded PURE project aims to develop precisely functionalised adsorbents. The project has brought together an interdisciplinary team of leading scientists from academia and industry with expertise in biology, chemistry, computational modelling, materials science, bioprocess engineering and applied social sciences.

Objective

Biopharmaceutical drugs save lives and drastically improve well-being. The number of new bio-drugs approved or in pipeline is rising but only 1/4 of patients have access to them. Bioseparation is a critical step in biopharmaceuticals manufacture. Bioseparation processes have low productivity, and are responsible for the environmental footprint and high cost of manufacturing. They use polymeric adsorbents decorated with affinity ligands that increase the selective capture of the required bio-drug. Current adsorbents originate slow processes with low capacity due to diffusive transport and the uncontrolled heterogeneous distribution of affinity ligands. Only a radical change in purification technologies can reduce the environmental footprint of biopharma industry, and increase productivity, making biopharmaceuticals quickly accessible to all.
PURE envisions the pioneering of precisely functionalised purification nanofibers using principles of scalable biotechnological processes. For the first time, affinity ligands are introduced into convective adsorbents in a site-directed oriented manner and predefined spatial arrangement. Scientific and engineering principles on living organisms are combined to produce the biobased adsorbents of the future, putting Europe in the forefront of sustainable and patient-oriented biopharma. PURE brings together leading scientists and a SME as a highly interdisciplinary team with expertise in biology, chemistry, computational modelling, materials science, bioprocess engineering and applied social sciences.
The new scientific knowledge and technological paradigm established in PURE have a wide window of opportunities. The scalable bioproduction of fibers with uniform ligand functionalization at predicted sites has never been achieved, and is currently limiting the performance of materials, namely in medical and technical applications. PURE revolutionizes the way advanced functional materials are thought today, and enables a new future.

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

RIA - Research and Innovation action

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-FETOPEN-2018-2020

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Coordinator

UNIVERSIDADE NOVA DE LISBOA
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 100 036,18
Address
CAMPUS DE CAMPOLIDE
1099 085 Lisboa
Portugal

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Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 100 036,18

Participants (3)

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