Precisely Patterned Nanofibers for High Performance Bioseparations

Project Information

PURE

Grant agreement ID: 899732

DOI

10.3030/899732

Project closed

EC signature date 26 May 2020

Start date 1 October 2020

End date 31 March 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 2 999 537,50

EU contribution

€ 2 999 537,50

Coordinated by

UNIVERSIDADE NOVA DE LISBOA
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (3)

Bioproduction of non-canonical amino acids

At least 500 mg of reactive ncAA AhA will be produced by biotechnological means

Bioproduction of unmodified spidroins

At least 500 mg of unmodified spidroins will be biologically produced

Production of activated affinity ligands

At least 250 mg of each activated affinity ligand will be attained The affinity ligands selective for factor VIII Mabs VLPs and protein A will be produced and modified with DBCO for further modification of labeled spidroin

Open Research Data Pilot (1)

Data Management Plan

Data Management PlanA detailed Data Management Plan will be created at the beginning of the project to ensure that all data is findable accessible interoperable and reusable FAIR The plan will be harmonized with a knowledge protection plan IPR plan

Documents, reports (1)

Dissemination and Exploitation Plan

Dissemination and Exploitation Plan at the end of the first Reporting Period RP1 M12

Websites, patent fillings, videos etc. (1)

PURE webportal operational

Publications

Peer reviewed articles (8)

Heparin-affinity chromatography is a generic purification platform for chimeric gag VLPs displaying different viral surface antigens

Author(s): Alexander M. Zollner, Leticia Guzman Ruiz, Viktoria Mayer, Stefanie Stohl, Leo A. Jakob, Nico Lingg, Miriam Klausberger, Alois Jungbauer, Patricia Pereira Aguilar
Published in: Separation and Purification Technology, Issue 340, 2024, Page(s) 126673, ISSN 1383-5866
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.seppur.2024.126673

Design and evolution of a synthetic small protein scaffold based on the WW domain

Author(s): Dias AMGC, Teixeira GDG, Barbosa AJM, Goncalves J, Iranzo O, Roque ACA
Published in: Protein Science, 2025, ISSN 1018-4783
Publisher: Protein Science
DOI: 10.1002/pro.70164

Enhancing NA immunogenicity through novel VLP designs.

Author(s): Leticia Guzman Ruiz, Alexander M. Zollner, Irene Hoxie, Jan Küchler, Christina Hausjell, Tomas Mesurado, Florian Krammer, Alois Jungbauer, Patricia Pereira Aguilar, Miriam Klausberger, Reingard Grabherr
Published in: Vaccine, Issue 42, 2024, Page(s) 126270, ISSN 0264-410X
Publisher: Elsevier BV
DOI: 10.1016/j.vaccine.2024.126270

Rational design of a small peptidomimetic ligand to capture a viral spike protein

Author(s): Carlos Filipe Santos Costa, Iana Lychko, Carolina Mota Natal, Arménio Jorge Moura Barbosa, Ana Margarida Gonçalves Carvalho Dias, Ana Cecília Afonso Roque
Published in: Separation and Purification Technology, Issue 366, 2025, Page(s) 132778, ISSN 1383-5866
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.seppur.2025.132778

Suitable electrospinning approaches for recombinant spider silk proteins

Author(s): Christoph Sommer, Thomas Scheibel
Published in: Open Ceramics, Issue 15, 2023, Page(s) 100420, ISSN 2666-5395
Publisher: Elsevier
DOI: 10.1016/j.oceram.2023.100420

Native, engineered and de novo designed ligands targeting the SARS-CoV-2 spike protein

Author(s): Costa, Carlos Filipe Santos; Barbosa, Arménio J. M.; Dias, Ana Margarida Gonçalves Carvalho; Roque, Ana Cecília A.
Published in: Biotechnology Advances, Issue 59, 2022, Page(s) 107986, ISSN 0734-9750
Publisher: Elsevier BV
DOI: 10.1016/j.biotechadv.2022.107986

Cephalopod proteins for bioinspired and sustainable biomaterials design

Author(s): Iana Lychko, Inês Padrão, Afonso Vicente Eva, Catarina Alexandra Oliveira Domingos, Henrique Miguel Aljustrel da Costa, Ana Margarida Gonçalves Carvalho Dias, Ana Cecília Afonso Roque
Published in: Materials Today Bio, Issue 31, 2025, Page(s) 101644, ISSN 2590-0064
Publisher: Elsevier BV
DOI: 10.1016/j.mtbio.2025.101644

Solvent modulation in peptide sub-microfibers obtained by solution blow spinning

Author(s): Ana Margarida Gonçalves Carvalho Dias, Cícero Cena, Viviane Lutz-Bueno, Raffaele Mezzenga, Ana Marques, Isabel Ferreira, Ana Cecília Afonso Roque
Published in: Frontiers in Chemistry, Issue 10, 2022, ISSN 2296-2646
Publisher: Frontiers Media SA
DOI: 10.3389/fchem.2022.1054347

Thesis and dissertations (12)

To be defined

Author(s): Alexander Zollner
Published in: 2025
Publisher: BOKU

Title to be defined

Author(s): Christoph Sommer
Published in: 2025
Publisher: Bayreuth

Design and Production of functional protein-based materials

Author(s): Henrique Costa
Published in: 2024
Publisher: Universidade NOVA de Lisboa

Immobilization of antibodies on non-wovens made of recombinant spyder silk proteins

Author(s): Charlotte Leonhardt
Published in: 2021
Publisher: Universitat Bayreuth

Production, functionalization and characterization of protein-based Materials

Author(s): Catarina Domingos
Published in: 2026
Publisher: Universidade NOVA de Lisboa

Affinity reagents towardsSars-cov-2

Author(s): Carlos Costa
Published in: 2025
Publisher: Universidade NOVA de Lisboa

Novel affinity adsorbents for metal-free purification of a solubility tag

Author(s): Carolina Natal
Published in: 2027
Publisher: Universidade NOVA de Lisboa

Production of non-woven meshes based on modified eADF4(Ω16) spider silk proteins for the immobilization of antibodies

Author(s): Amelie Linder
Published in: 2022
Publisher: Universitat Bayreuth

Novel Affinity-Based Technologies for Targetting Distinct Biological Systems

Author(s): Eduardo Almeida
Published in: 2024
Publisher: iBET

Title to be defined 2

Author(s): Claudia Lacombe
Published in: 2025
Publisher: BOKU

Exploring alternative culture media for protein recombinant expression in bacterial hosts

Author(s): Renata Costa
Published in: 2025
Publisher: Universidade NOVA de Lisboa

Sustainable fibers for bioseparation: innovation, market transfer and a collaborative model

Author(s): José Pedro Fradique Lourenço Dias Dinis
Published in: 2022
Publisher: Universidade NOVA de Lisboa