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Ultrasound peripheral interface and in-vitro model of human somatosensory system and muscles for motor decoding and restoration of somatic sensations in amputees

Project description

Using ultrasound stimulation to restore sensation of limb prostheses

Limb prosthetics used in amputees lack natural and tactile sensations. The EU-funded SOMA project aims to develop a new interface based on algorithms that enable the sensing of mechanical pressure, pain and changes in temperature. Using cutting-edge tissue engineering technology and computational modelling, scientists plan to develop an in vitro innervated skin model to study sensory receptors and the afferent neural signals. Understanding the spatiotemporal relationships between cutaneous stimuli and neural signals will help scientists apply focussed ultrasound stimulation to the peripheral nervous system. This is expected to provide amputees with sensor–motor control of their upper-limb prosthesis.

Objective

The SOMA project tackles three grand challenges in the field of upper-limb neuroprosthetics: a) to develop a completely novel low invasive peripheral interface for restoring natural and multimodal tactile sensations in amputee subjects, with high selectivity and discrimination capabilities thanks to focused UltraSound (US) stimulation, b) to develop and validate an in-vitro model of the innervated natural skin and its sensory receptors, through the application of cutting edge tissue engineering technology and neurocomputational modelling, for the study of spatio-temporal relationships between cutaneous stimuli and afferent neural signals, and for the validation of stimulation techniques of the Peripheral Nervous System (PNS), c) to demonstrate the effectiveness of the newly developed interface through the closed-loop sensori-motor control of an upper-limb prosthesis..
The novel low invasive peripheral interface will rely on focused US probes, implantable wireless technologies and new encoding algorithms capable of generating multimodal sensations related to mechanoreceptors (for mechanical pressure), nociceptors (for pain) and thermoreceptors (for changes in temperature).
The in-vitro model of the somatosensory system will be composed of a biohybrid fully innervated sensitive skin, which replicates in-vitro the complex cutaneous somatosensory system of the human skin. The project aims to experimentally validate the in-vitro model, to unravel the role of the sense of touch in both exteroception and proprioception and to provide as ultimate goal a test-bed useful to investigate and test new stimulation techniques. The development of the novel peripheral interface and the in-vitro model will be carried out in parallel through a comparative analysis with the most advanced state-of-the art stimulation techniques and an experimental validation with in-vivo tests on animal models.
Finally, a clinical validation on one amputee subject will be carried out.

Call for proposal

H2020-FETOPEN-2018-2020

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Sub call

H2020-FETOPEN-2018-2019-2020-01

Coordinator

UNIVERSITA CAMPUS BIO MEDICO DI ROMA
Net EU contribution
€ 576 250,00
Address
VIA ALVARO DEL PORTILLO 21
00128 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Higher or Secondary Education Establishments
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Total cost
€ 576 250,00

Participants (6)