Ultrasound peripheral interface and in-vitro model of human somatosensory system and muscles for motor decoding and restoration of somatic sensations in amputees

Project Information

SOMA

Grant agreement ID: 899822

DOI

10.3030/899822

Project closed

EC signature date 26 May 2020

Start date 1 September 2020

End date 28 February 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 2 999 998,75

EU contribution

€ 2 999 998,75

Coordinated by

UNIVERSITA CAMPUS BIO MEDICO DI ROMA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Project website and communication channels

Open Research Data Pilot (1)

Data Management Plan (DMP)

Report on Data Management Plan

Documents, reports (2)

Report on in-vivo US stimulation and recording
Functional and histological results of biocompatibility and safety

Report on functional and histological results of biocompatibility and safety

Publications

Peer reviewed articles (26)

Kinematics of individual muscle units in natural contractions measured in vivo using ultrafast ultrasound

Author(s): Emma Lubel; Bruno Grandi Sgambato; Deren Y Barsakcioglu; Jaime Ibáñez; Meng-Xing Tang; Dario Farina
Published in: Journal of Neural Engineering, 2022, ISSN 1741-2560
Publisher: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ac8c6c

Method for Automatic Slippage Detection With Tactile Sensors Embedded in Prosthetic Hands

Author(s): Rocco A. Romeo, Clemente Lauretti, Cosimo Gentile, Eugenio Guglielmelli, Loredana Zollo
Published in: IEEE Transactions on Medical Robotics and Bionics, Issue 3/2, 2021, Page(s) 485-497, ISSN 2576-3202
Publisher: IEEE
DOI: 10.1109/tmrb.2021.3060032

Restoring somatotopic sensory feedback in lower limb amputees through non-invasive nerve stimulation

Author(s): Andrea Demofonti, Marco Germanotta, Andrea Zingaro, Gaia Bailo, Sabina Insalaco, Francesca Cordella, Irene Giovanna Aprile, Loredana Zollo
Published in: Cyborg and Bionic Systems, 2025, ISSN 2692-7632
Publisher: Science Partner Journals
DOI: 10.34133/cbsystems.0243

Repair of long peripheral nerve defects in sheep: a translational model for nerve regeneration

Author(s): Contreras E, Traserra S, Bolívar S, Forés J, Jose-Cunilleras E, Delgado-Martínez I, García F, Udina E, Navarro X.
Published in: International Journal of Molecular Science, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24021333

Hierarchical strategy for sEMG classification of the hand/wrist gestures and forces of transradial amputees

Author(s): Francesca Leone, Federico Mereu, Cosimo Gentile, Francesca Cordella, Emanuele Gruppioni, Loredana Zollo
Published in: Frontiers in Neurorobotics, Issue 17, 2023, ISSN 1662-5218
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnbot.2023.1092006

A High-Voltage Differential SPDT T/R Switch for Ultrasound Systems

Author(s): Yaohua Zhang, Dai Jiang, Andreas Demosthenous
Published in: IEEE Transactions on Circuits and Systems I: Regular Papers, Issue 71, 2024, Page(s) 5129-5140, ISSN 1549-8328
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tcsi.2024.3426558

Mechanical and thermal stimulation for studying the somatosensory system: a review on devices and methods

Author(s): M Sperduti, N L Tagliamonte, F Taffoni, E Guglielmelli, L Zollo
Published in: Journal of Neural Engineering, Issue 21, 2024, Page(s) 051001, ISSN 1741-2560
Publisher: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ad716d

Validation of Magneto-Inertial Measurement Units for Upper-Limb Motion Analysis Through an Anthropomorphic Robot

Author(s): M. Lapresa, C. Tamantini, F. Scotto di Luzio, M. Ferlazzo, G. Sorrenti, F. Corpina, L. Zollo
Published in: IEEE Sensors Journal, 2022, ISSN 1530-437X
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jsen.2022.3193313

A multiscale approach to axon and nerve stimulation modeling: A review

Author(s): Mattia STEFANO, Francesca Cordella, Alessandro Loppini, Simonetta Filippi, Loredana Zollo
Published in: IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2021, ISSN 1534-4320
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tnsre.2021.3054551

Eliciting Force and Slippage in Upper Limb Amputees Through Transcutaneous Electrical Nerve Stimulation (TENS)

Author(s): A. Scarpelli, A. Demofonti, F. Cordella, U. Coffa, F. Mereu, E. Gruppioni, L. Zollo
Published in: IEEE Transactions on Neural Systems and Rehabilitation Engineering, Issue 32, 2024, Page(s) 3006-3017, ISSN 1534-4320
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tnsre.2024.3443398

Performance Assessment of Thermal Sensors for Hand Prostheses

Author(s): Enrica Stefanelli, Marika Sperduti, Francesca Cordella, Nevio Luigi Tagliamonte, Loredana Zollo
Published in: IEEE Sensors Journal, Issue 24, 2024, Page(s) 27559-27569, ISSN 1530-437X
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jsen.2024.3431274

Accurate Identification of Motoneuron Discharges From Ultrasound Images Across the Full Muscle Cross-Section

Author(s): Emma Lubel, Robin Rohlén, Bruno Grandi Sgambato, Deren Y Barsakcioglu, Jaime Ibáñez, Meng-Xing Tang, Dario Farina
Published in: IEEE Transactions on Biomedical Engineering, Issue 71, 2024, Page(s) 1466-1477, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2023.3340019

Assessment of focused ultrasound stimulation to induce peripheral nerve activity and potential damage in vivo

Author(s): Bruno Rodríguez-Meana, Eva Santos-Nogueira, Sònia Trujillo-Vázquez, Anette Jakob, Esther Udina, Marc Fournelle, Xavier Navarro
Published in: Frontiers in Neurology, Issue 15, 2024, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2024.1346412

Assessing the impact of degree of fusion and muscle fibre twitch shape variation on the accuracy of motor unit discharge time identification from ultrasound images

Author(s): Robin Rohlén, Emma Lubel, Dario Farina
Published in: Biomedical Signal Processing and Control, Issue 100, 2025, Page(s) 107002, ISSN 1746-8094
Publisher: Elsevier BV
DOI: 10.1016/j.bspc.2024.107002

Study of Electrical Neural Stimulation Effects Using Extraneural and Intraneural Electrodes

Author(s): Mattia Stefano, Francesca Cordella, Giulia Cozza, Anna Lisa Ciancio, Loredana Zollo
Published in: Applied Sciences, Issue 13, 2023, Page(s) 6267, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app13106267

Hand Prosthesis Sensorimotor Control Inspired by the Human Somatosensory System

Author(s): Enrica Stefanelli, Francesca Cordella, Cosimo Gentile, Loredana Zollo
Published in: Robotics, Issue 12, 2025, Page(s) 136, ISSN 2218-6581
Publisher: MDPI
DOI: 10.3390/robotics12050136

High Performance Wearable Ultrasound as a Human-Machine Interface for Wrist and Hand Kinematic Tracking

Author(s): Bruno Grandi Sgambato, Milia H Hasbani, Deren Y Barsakcioglu, Jaime Ibáñez, Anette Jakob, Marc Fournelle, Meng-Xing Tang, Dario Farina
Published in: IEEE Transactions on Biomedical Engineering, Issue 71, 2024, Page(s) 484-493, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2023.3307952

Integrated Circuits for Medical Ultrasound Applications: Imaging and Beyond

Author(s): Yaohua Zhang; Andreas Demosthenous
Published in: IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, 2021, ISSN 1932-4545
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbcas.2021.3120886

Control Strategies and Performance Assessment of Upper-Limb TMR Prostheses: A Review

Author(s): F. Mereu, F. Leone, C. Gentile, F. Cordella, E. Gruppioni, L. Zollo
Published in: Sensors, 2021, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21061953

Design of a modular and compliant wrist module for upper limb prosthetics

Author(s): A. Demofonti, G. Carpino, N. L. Tagliamonte, G. Baldini, L. Bramato, L. Zollo
Published in: The Anatomical Record, 2022, ISSN 1932-8494
Publisher: John Wiley and Co.
DOI: 10.1002/ar.24911

Spatial decomposition of ultrafast ultrasound images to identify motor unit activity – A comparative study with intramuscular and surface EMG

Author(s): Robin Rohlén, Emma Lubel, Bruno Grandi Sgambato, Christian Antfolk, Dario Farina
Published in: Journal of Electromyography and Kinesiology, Issue 73, 2023, Page(s) 102825, ISSN 1050-6411
Publisher: Elsevier BV
DOI: 10.1016/j.jelekin.2023.102825

Evaluation of the effects of focused ultrasound stimulation on the central nervous system through a multiscale simulation approach

Author(s): A. Scarpelli, M. Stefano, F. Cordella, L. Zollo
Published in: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2022.1034194

Hierarchical Human-Inspired Control Strategies for Prosthetic Hands

Author(s): Cosimo Gentile, Francesca Cordella, Loredana Zollo
Published in: Sensors, Issue 22, 2024, Page(s) 2521, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s22072521

Analysis of Hand Intra-Finger Couplings During Flexion Movements in the Free Space

Author(s): Martina Lapresa, Alessandro Ceccarelli, Fabrizio Taffoni, Nevio Luigi Tagliamonte, Loredana Zollo, Francesca Cordella
Published in: IEEE Access, Issue 11, 2023, Page(s) 90084-90093, ISSN 2169-3536
Publisher: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/access.2023.3307417

Non-linearity in motor unit velocity twitch dynamics: Implications for ultrafast ultrasound source separation

Author(s): Emma Lubel, Bruno Grandi Sgambato, Robin Rohlén, Jaime Ibáñez, Deren Y Barsakcioglu, Meng-Xing Tang, Dario Farina
Published in: EEE TRANSACTIONS ON NEURAL SYSTEMS ANDREHABILITATION ENGINEERING, 2023, ISSN 1534-4320
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1101/2023.03.24.533983

A parallel classification strategy to simultaneous control elbow, wrist, and hand movements

Author(s): Francesca Leone; Cosimo Gentile; Francesca Cordella; Emanuele Gruppioni; Eugenio Guglielmelli; Loredana Zollo
Published in: Journal of NeuroEngineering and Rehabilitation, 2022, ISSN 1743-0003
Publisher: BioMed Central
DOI: 10.1186/s12984-022-00982-z

Conference proceedings (2)

Electrical stimulation of the human median nerve: A comparison between anatomical and simplified simulation models

Author(s): Mattia Stefano, Francesca Cordella, Salvatore Maria Li Gioi, Loredana Zollo
Published in: 2021 10th International IEEE/EMBS Conference on Neural Engineering (NER), 2021, Page(s) 769-772, ISBN 978-1-7281-4337-8
Publisher: IEEE
DOI: 10.1109/ner49283.2021.9441187

Modulation of sensation intensity in the lower limb via Transcutaneous Electrical Nerve Stimulation

Author(s): Demofonti A., Scarpelli A., Cordella F. and Zollo L.
Published in: 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2021
Publisher: IEEE

Book chapters (1)

Neural electrodes for long-term tissue interfaces. In Guçlu B (ed): “

Author(s): del Valle J, Rodríguez-Meana B, Navarro X
Published in: Somatosensory Feedback for Neuroprosthetics, Issue Single, 2021, Page(s) 509-536, ISBN 978-0-12-822828-9
Publisher: Elsevier