CORDIS
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CORDIS

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Commercialization of catalytic enhancers targeting IDO1 for multiple sclerosis

Project information

Grant agreement ID: 899838

Status

Grant agreement signed

  • Start date

    1 September 2020

  • End date

    28 February 2022

Funded under:

H2020-EU.1.1.

Hosted by:

UNIVERSITA DEGLI STUDI DI PERUGIA

Italy

Objective

ENHANCIDO will assess the commercial and technical feasibility of novel immune tolerance-inducing small molecules as superior treatments for multiple sclerosis (MS). MS is a chronic neurodegenerative disease affecting 2.3 million people worldwide. 85% of MS cases belong to the relapsing-remitting subtype (RRMS) characterised by bouts of recurring and debilitating relapses followed by unstoppable loss of neurological functions. Unfortunately, current treatments for RRMS are ineffective, poorly tolerated, and expensive. They cannot prevent disease progression and only provide symptomatic relief. Furthermore, severe adverse effects and inconvenient administration routes contribute to high rates of treatment discontinuation amongst patients (30-80%). To tackle these issues, Prof. Ursula Grohmann has developed a set of novel, orally administered, effective, and safe small molecules that induce immune tolerance to alter the previously inexorable course of the disease. These first-in-class molecules are positive allosteric modulators (PAMs) of the immunoregulatory enzyme IDO1. Prof. Grohmann’s PAMs increase IDO1 activity, reduce disease severity in mouse models of acute MS and show no off-target effects. Within ENHANCIDO, we will assess whether IDO1 PAMs are feasible as breakthrough treatments for RRMS. Firstly, we will validate their technical feasibility by evaluating their efficacy, pharmacokinetics and pharmacodynamics in RRMS mouse models. Subsequently, commercial feasibility will be determined by verifying IP position and strategy, performing in-depth market and competitor analyses, and finally consolidating these into a business plan to establish the best path to commercialisation. Successful commercialisation of IDO1 PAMs could reduce the profound socioeconomic burden of MS, extend and improve the lives of patients, and provide the pharmaceutical industry with a profitable, first-in-kind drug that can potentially be used for other autoimmune diseases.

Host institution

UNIVERSITA DEGLI STUDI DI PERUGIA

Address

Piazza Dell Universita 1
06123 Perugia

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 150 000

Beneficiaries (1)

UNIVERSITA DEGLI STUDI DI PERUGIA

Italy

EU Contribution

€ 150 000

Project information

Grant agreement ID: 899838

Status

Grant agreement signed

  • Start date

    1 September 2020

  • End date

    28 February 2022

Funded under:

H2020-EU.1.1.

Hosted by:

UNIVERSITA DEGLI STUDI DI PERUGIA

Italy