Improving COgnition in Down syndrome

Project Information

ICOD

Grant agreement ID: 899986

DOI

10.3030/899986

EC signature date 21 January 2021

Start date 1 February 2021

End date 31 July 2027

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 6 123 880,75

EU contribution

€ 5 989 839,50

Coordinated by

CONSORCIO MAR PARC DE SALUT DE BARCELONA
Spain

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (7)

First study subject approvals package for phase I in healthy volunteers (SAD, MAD, FE)

AEMPS approval to conduct the 3 phase I studies in healthy volunteers SAD MAD and FEThis package will include a final version of study protocol as approved by regulatory agencyiesethics committees a study registration number in EudraCT European Union Drug Regulating Authorities Clinical Trials Database and copies of opinions andor authorization from Institutional Data Protection Officer and National Data Protection Authority as appropriate

Report on communication activity in Italy

Summary of the communications activities performed in Italy

Report on Scientific meetings participations

Report of the participation to international scientific meetings with posters orand talks from the researchers involved in the project such as the Annual Meeting of the American Society for Neuroscience Meeting SfN and most importantly the Trisomy21 Research Society T21RS International Research Conference IRC

ICOD Project Management handbook

Handbook summarizing the operating rules of the project management office PMO

Report of communication activity in Spain

Summary of the communications activities performed in Spain

Intermediary report on dissemination and communication activities

Report summarizing all the dissemination and communication activities (educational days, press conferences, oopen public onferences, articles or press releases, …) performed during the first half part of the ICOD project.

Report of communication activity in France

Summary of the communications activities performed in France

Websites, patent fillings, videos etc. (2)

Project website online

Availability of the project website online with external contribution of EDSA and national DS associations

Corporate identity, video & flyer

Availability of a project logo and a professional corporate identity which will appear on all documents publications and ICOD presentations Flyers will be produced to be hand out at events at which the ICOD project will participate Youtube channel with videos conveyed on social networking sites for young people

Publications

Non-peer reviewed articles (1)

State‐of‐the‐art therapy for Down syndrome

Author(s): Nicola Lorenzon, Juanluis Musoles‐Lleó, Federica Turrisi, Maria Gomis‐González, Rafael De La Torre, Mara Dierssen
Published in: Developmental Medicine & Child Neurology, Issue 65, 2024, Page(s) 870-884, ISSN 0012-1622
Publisher: Mac Keith Press
DOI: 10.1111/dmcn.15517

Peer reviewed articles (2)

Low TGF-β1 plasma levels are associated with cognitive decline in Down syndrome

Author(s): Margherita Grasso, Annamaria Fidilio, Francesca L’Episcopo, Marilena Recupero, Concetta Barone, Maria Giulia Bacalini, Cristina Benatti, Maria Concetta Giambirtone, Giuseppe Caruso, Donatella Greco, Santo Di Nuovo, Corrado Romano, Raffaele Ferri, Serafino Buono, A. Claudio Cuello, Johanna M. C. Blom, Fabio Tascedda, Pier Vincenzo Piazza, Rafael De La Torre, Filippo Caraci
Published in: Frontiers in Pharmacology, Issue 15, 2024, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1379965

Searching for New Possible Peripheral Biomarkers of Cognitive Decline in Down Syndrome: The Role of IL-18 Pathway and its Interaction with TGF-β1 and TNF-α

Author(s): Margherita Grasso, Annamaria Fidilio, Francesca L’Episcopo, Marilena Recupero, Concetta Barone, Marta Lovino, Silvia Alboni, Maria Giulia Bacalini, Giuseppe Caruso, Donatella Greco, Serafino Buono, Rafael De La Torre, Fabio Tascedda, Johanna MC Blom, Cristina Benatti, Filippo Caraci
Published in: NeuroMolecular Medicine, Issue 28, 2026, ISSN 1559-1174
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s12017-025-08901-w

Other (1)

Living longer, living better : new advances in Down syndrome care

Author(s): Horizon
Published in: the EU research and Innovation Magazine, 2025
Publisher: Horizon Magazine