Improving COgnition in Down syndrome

Información del proyecto

ICOD

Identificador del acuerdo de subvención: 899986

DOI

10.3030/899986

Fecha de la firma de la CE 21 Enero 2021

Fecha de inicio 1 Febrero 2021

Fecha de finalización 31 Julio 2027

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 6 123 880,75

Aportación de la UE

€ 5 989 839,50

Coordinado por

CONSORCIO MAR PARC DE SALUT DE BARCELONA
Spain

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (7)

First study subject approvals package for phase I in healthy volunteers (SAD, MAD, FE)

AEMPS approval to conduct the 3 phase I studies in healthy volunteers SAD MAD and FEThis package will include a final version of study protocol as approved by regulatory agencyiesethics committees a study registration number in EudraCT European Union Drug Regulating Authorities Clinical Trials Database and copies of opinions andor authorization from Institutional Data Protection Officer and National Data Protection Authority as appropriate

Report on communication activity in Italy

Summary of the communications activities performed in Italy

Report on Scientific meetings participations

Report of the participation to international scientific meetings with posters orand talks from the researchers involved in the project such as the Annual Meeting of the American Society for Neuroscience Meeting SfN and most importantly the Trisomy21 Research Society T21RS International Research Conference IRC

ICOD Project Management handbook

Handbook summarizing the operating rules of the project management office PMO

Report of communication activity in Spain

Summary of the communications activities performed in Spain

Intermediary report on dissemination and communication activities

Report summarizing all the dissemination and communication activities (educational days, press conferences, oopen public onferences, articles or press releases, …) performed during the first half part of the ICOD project.

Report of communication activity in France

Summary of the communications activities performed in France

Websites, patent fillings, videos etc. (2)

Project website online

Availability of the project website online with external contribution of EDSA and national DS associations

Corporate identity, video & flyer

Availability of a project logo and a professional corporate identity which will appear on all documents publications and ICOD presentations Flyers will be produced to be hand out at events at which the ICOD project will participate Youtube channel with videos conveyed on social networking sites for young people

Publicaciones

Non-peer reviewed articles (1)

State‐of‐the‐art therapy for Down syndrome

Autores: Nicola Lorenzon, Juanluis Musoles‐Lleó, Federica Turrisi, Maria Gomis‐González, Rafael De La Torre, Mara Dierssen
Publicado en: Developmental Medicine & Child Neurology, Edición 65, 2024, Página(s) 870-884, ISSN 0012-1622
Editor: Mac Keith Press
DOI: 10.1111/dmcn.15517

Peer reviewed articles (2)

Low TGF-β1 plasma levels are associated with cognitive decline in Down syndrome

Autores: Margherita Grasso, Annamaria Fidilio, Francesca L’Episcopo, Marilena Recupero, Concetta Barone, Maria Giulia Bacalini, Cristina Benatti, Maria Concetta Giambirtone, Giuseppe Caruso, Donatella Greco, Santo Di Nuovo, Corrado Romano, Raffaele Ferri, Serafino Buono, A. Claudio Cuello, Johanna M. C. Blom, Fabio Tascedda, Pier Vincenzo Piazza, Rafael De La Torre, Filippo Caraci
Publicado en: Frontiers in Pharmacology, Edición 15, 2024, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1379965

Searching for New Possible Peripheral Biomarkers of Cognitive Decline in Down Syndrome: The Role of IL-18 Pathway and its Interaction with TGF-β1 and TNF-α

Autores: Margherita Grasso, Annamaria Fidilio, Francesca L’Episcopo, Marilena Recupero, Concetta Barone, Marta Lovino, Silvia Alboni, Maria Giulia Bacalini, Giuseppe Caruso, Donatella Greco, Serafino Buono, Rafael De La Torre, Fabio Tascedda, Johanna MC Blom, Cristina Benatti, Filippo Caraci
Publicado en: NeuroMolecular Medicine, Edición 28, 2026, ISSN 1559-1174
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s12017-025-08901-w

Other (1)

Living longer, living better : new advances in Down syndrome care

Autores: Horizon
Publicado en: the EU research and Innovation Magazine, 2025
Editor: Horizon Magazine