Improving COgnition in Down syndrome

Informations projet

ICOD

N° de convention de subvention: 899986

DOI

10.3030/899986

Date de signature de la CE 21 Janvier 2021

Date de début 1 Février 2021

Date de fin 31 Juillet 2027

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 6 123 880,75

Contribution de l’UE

€ 5 989 839,50

Coordonné par

CONSORCIO MAR PARC DE SALUT DE BARCELONA
Spain

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (7)

First study subject approvals package for phase I in healthy volunteers (SAD, MAD, FE)

AEMPS approval to conduct the 3 phase I studies in healthy volunteers SAD MAD and FEThis package will include a final version of study protocol as approved by regulatory agencyiesethics committees a study registration number in EudraCT European Union Drug Regulating Authorities Clinical Trials Database and copies of opinions andor authorization from Institutional Data Protection Officer and National Data Protection Authority as appropriate

Report on communication activity in Italy

Summary of the communications activities performed in Italy

Report on Scientific meetings participations

Report of the participation to international scientific meetings with posters orand talks from the researchers involved in the project such as the Annual Meeting of the American Society for Neuroscience Meeting SfN and most importantly the Trisomy21 Research Society T21RS International Research Conference IRC

ICOD Project Management handbook

Handbook summarizing the operating rules of the project management office PMO

Report of communication activity in Spain

Summary of the communications activities performed in Spain

Intermediary report on dissemination and communication activities

Report summarizing all the dissemination and communication activities (educational days, press conferences, oopen public onferences, articles or press releases, …) performed during the first half part of the ICOD project.

Report of communication activity in France

Summary of the communications activities performed in France

Websites, patent fillings, videos etc. (2)

Project website online

Availability of the project website online with external contribution of EDSA and national DS associations

Corporate identity, video & flyer

Availability of a project logo and a professional corporate identity which will appear on all documents publications and ICOD presentations Flyers will be produced to be hand out at events at which the ICOD project will participate Youtube channel with videos conveyed on social networking sites for young people

Publications

Non-peer reviewed articles (1)

State‐of‐the‐art therapy for Down syndrome

Auteurs: Nicola Lorenzon, Juanluis Musoles‐Lleó, Federica Turrisi, Maria Gomis‐González, Rafael De La Torre, Mara Dierssen
Publié dans: Developmental Medicine & Child Neurology, Numéro 65, 2024, Page(s) 870-884, ISSN 0012-1622
Éditeur: Mac Keith Press
DOI: 10.1111/dmcn.15517

Peer reviewed articles (2)

Low TGF-β1 plasma levels are associated with cognitive decline in Down syndrome

Auteurs: Margherita Grasso, Annamaria Fidilio, Francesca L’Episcopo, Marilena Recupero, Concetta Barone, Maria Giulia Bacalini, Cristina Benatti, Maria Concetta Giambirtone, Giuseppe Caruso, Donatella Greco, Santo Di Nuovo, Corrado Romano, Raffaele Ferri, Serafino Buono, A. Claudio Cuello, Johanna M. C. Blom, Fabio Tascedda, Pier Vincenzo Piazza, Rafael De La Torre, Filippo Caraci
Publié dans: Frontiers in Pharmacology, Numéro 15, 2024, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1379965

Searching for New Possible Peripheral Biomarkers of Cognitive Decline in Down Syndrome: The Role of IL-18 Pathway and its Interaction with TGF-β1 and TNF-α

Auteurs: Margherita Grasso, Annamaria Fidilio, Francesca L’Episcopo, Marilena Recupero, Concetta Barone, Marta Lovino, Silvia Alboni, Maria Giulia Bacalini, Giuseppe Caruso, Donatella Greco, Serafino Buono, Rafael De La Torre, Fabio Tascedda, Johanna MC Blom, Cristina Benatti, Filippo Caraci
Publié dans: NeuroMolecular Medicine, Numéro 28, 2026, ISSN 1559-1174
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s12017-025-08901-w

Other (1)

Living longer, living better : new advances in Down syndrome care

Auteurs: Horizon
Publié dans: the EU research and Innovation Magazine, 2025
Éditeur: Horizon Magazine