Radiation risk appraisal for detrimental effects from medical exposure during management of patients with lymphoma or brain tumour

Project Information

SINFONIA

Grant agreement ID: 945196

DOI

10.3030/945196

Project closed

EC signature date 14 May 2020

Start date 1 September 2020

End date 31 August 2024

Funded under

• Euratom

Total cost

€ 5 999 998,75

EU contribution

€ 5 999 997,50

Coordinated by

EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (22)

Report on cumulative doses and risks of 100 patients with lymphoma and brain tumours in a retrospective patient study
Methodology of an advanced computational approach and generation of new dose data for comforters in NUM
Report on recommendations from the SINFONIA panels on diagnostic radiology, nuclear medicine and radiation therapy
New dose data for specific procedures of staff in NUM
Requirements and design of the prototype architecture
Report on training courses for SINFONIA collaborators
Individual mutation levels induced by RT

Report describing stable aberration frequencies in PBL of patients undergoing RT.

Factors that influence the risk of SMN

Report summarising factors that influence the risk of SMN and optimal methods of risk transfer

Final report on dissemination activities
Radiation sensitivity biomarker for SMN

Report comparing DNA repair capacities of patients with primary and secondary cancers.

Factsheets and other information for the general public on doses from medical exposure and their impact on the risk for patients
Genetic biomarker for SMN

Report comparing SNP in patients with primary and secondary cancers.

Radionuclide dispersion simulations results
Report on dosimetry, radiobiology and radiation protection education in the field of medical imaging and radiation oncology

Report on dosimetry radiobiology and radiation protection education in the field of medical imaging and radiation oncology

Intermediate report on SINFONIA dissemination activities
Platform description, data model and protocols

Platform description data model and protocols

Context-aware integrated training module
Human, biota and aquatic biota study report

Human biota and aquatic biota study report

Final platform and algorithms integration
Field survey of staff dosimetry practice in proton radiotherapy centres
Updated Communication and Dissemination Plan and updated video
Methodological report on the development of a system for personalised dosimetry to account for in-field and out-of-field organ exposure from scatter dose during photon-based therapy, neutron-radiation and imaging in proton therapy

Methodological report on the development of a system for personalised dosimetry to account for infield and outoffield organ exposure from scatter dose during photonbased therapy neutronradiation and imaging in proton therapy

Other (5)

Software tool on personalised dosimetry in radiological imaging and deep-learning guided algorithms
Software tool on personalised dosimetry in PET-CT and deep learning-guided algorithms for automated construction of computational models
Software tool for risk appraisal using doses from radiological, nuclear medicine and radiation therapy procedures
Interactive MOOC on clinical dosimetry radiation risk analysis
Software tool on personalised dosimetry in photon-based radiation therapy imaging and deep-learning-guided algorithms

Publications

Peer reviewed articles (29)

Real-time, acquisition parameter-free voxel-wise patient-specific Monte Carlo dose reconstruction in whole-body CT scanning using deep neural networks

Author(s): Yazdan Salimi; Azadeh Akhavanallaf; Zahra Mansouri; Isaac Shiri; Habib Zaidi
Published in: European Radiology 2023, Issue 2, 2023, ISSN 1432-1084
Publisher: Springer
DOI: 10.1007/s00330-023-09839-y

Impact of medical radionuclide discharges on people and the environment

Author(s): J. Vives i Batlle, L. Sweeck, F. Fiengo Pérez
Published in: Journal of Environmental Radioactivity, Issue 272, 2024, Page(s) 107362, ISSN 0265-931X
Publisher: Elsevier BV
DOI: 10.1016/j.jenvrad.2023.107362

Rapid estimation of patient-specific organ doses using a deep learning network

Author(s): Myronakis M, Stratakis J, Damilakis J
Published in: Medical Physics, Issue 2023;1–9, 2023, ISSN 0094-2405
Publisher: American Association of Physicists in Medicine
DOI: 10.1002/mp.16356

Deep transformer-based personalized dosimetry from SPECT/CT images: a hybrid approach for [177Lu]Lu-DOTATATE radiopharmaceutical therapy

Author(s): Zahra Mansouri, Yazdan Salimi, Azadeh Akhavanallaf, Isaac Shiri, Eliluane Pirazzo Andrade Teixeira, Xinchi Hou, Jean-Mathieu Beauregard, Arman Rahmim, Habib Zaidi
Published in: European Journal of Nuclear Medicine and Molecular Imaging, Issue 51, 2024, Page(s) 1516-1529, ISSN 1619-7070
Publisher: Springer Verlag
DOI: 10.1007/s00259-024-06618-9

Range-shifter effects on the stray field in proton therapy measured with the variance-covariance method

Author(s): Eliasson L, Lillhök J, Bäck T, Billnert-Maróti R, Dasu A, Liszka M
Published in: Frontiers in Oncology, Issue 2022 Aug 2;12:882230., 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.882230

Peripheral organ equivalent dose estimation procedure in proton therapy

Author(s): Domingo C, Lagares JI, Romero-Expósito M, Sánchez-Nieto B, Nieto-Camero JJ, Terrón JA, Irazola L, Dasu A, Sánchez-Doblado F
Published in: Frontiers in Oncology, Issue 2022 May 25;12:882476, 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.882476

Medical applications of ionizing radiation and radiation protection for European patients, population and environment

Author(s): Thierry-Chef, Isabelle; Cardis, Elisabeth; Damilakis, John; Frija, Guy; Hierath, Monika; Hoeschen, Christop; EURAMED ROCC-N-ROLL consortia members
Published in: EPJ Nuclear Sci. Technol., Issue 8, 44, 2022, ISSN 2491-9292
Publisher: EDP SCIENCES S A
DOI: 10.1051/epjn/2022044

Fully automated explainable abdominal CT contrast media phase classification using organ segmentation and machine learning

Author(s): Yazdan Salimi, Zahra Mansouri, Ghasem Hajianfar, Amirhossein Sanaat, Isaac Shiri, Habib Zaidi
Published in: Medical Physics, Issue 51, 2024, Page(s) 4095-4104, ISSN 0094-2405
Publisher: American Association of Physicists in Medicine
DOI: 10.1002/mp.17076

Radiation exposure assessment of nuclear medicine staff administering [177Lu]Lu-DOTA-TATE with active and passive dosimetry

Author(s): Mercedes Riveira-Martin, Lara Struelens, José Muñoz Iglesias, Werner Schoonjans, Olga Tabuenca, José Manuel Nogueiras, Francisco Javier Salvador Gómez, Antonio López Medina
Published in: EJNMMI Physics, Issue 10, 2023, ISSN 2197-7364
Publisher: Springer Verlag
DOI: 10.1186/s40658-023-00592-1

Prevención de la exposición ocupacional a la radiación del personal de enfermería de Medicina Nuclear

Author(s): Interview with Riveira-Martin M
Published in: Archivos de Prevención de Riesgos Laborales, Issue 2023;26(3):34-38, 2023, ISSN 1138-9672
Publisher: Societat Catalana de Seguretat i Medicina del Treball (SCSMT)
DOI: 10.12961/aprl.2023.26.03.08

Range shifter contribution to neutron exposure of patients undergoing proton pencil beam scanning

Author(s): Maite Romero‐Expósito, Malgorzata Liszka, Athanasia Christou, Iuliana Toma‐Dasu, Alexandru Dasu
Published in: Medical Physics, Issue 51, 2024, Page(s) 5099-5108, ISSN 0094-2405
Publisher: American Association of Physicists in Medicine
DOI: 10.1002/mp.16897

Accuracy of patient-specific CT organ doses from Monte Carlo simulations: influence of CT-based voxel models

Author(s): Gwenny Verfaillie, Jeff Rutten, Yves D’Asseler, Klaus Bacher
Published in: Physical and Engineering Sciences in Medicine, Issue 47, 2024, Page(s) 989-1000, ISSN 2662-4729
Publisher: Springer Verlag
DOI: 10.1007/s13246-024-01422-z

Organomics

Author(s): Yazdan Salimi, Ghasem Hajianfar, Zahra Mansouri, Amirhosein Sanaat, Mehdi Amini, Isaac Shiri, Habib Zaidi
Published in: Clinical Nuclear Medicine, Issue 49, 2024, Page(s) 899-908, ISSN 0363-9762
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/rlu.0000000000005400

Deep learning-based fully automated Z-axis coverage range definition from scout scans to eliminate overscanning in chest CT imaging

Author(s): Yazdan Salimi; Isaac Shiri; Azadeh Akhavanallaf; Zahra Mansouri; Abdollah Saberi Manesh; Amirhossein Sanaat; Masoumeh Pakbin; Dariush Askari; Saleh Sandoughdaran; Ehsan Sharifipour; Hossein Arabi; Habib Zaidi
Published in: Insights into Imaging, Vol 12, Iss 1, Pp 1-16 (2021), Issue 1, 2021, ISSN 1869-4101
Publisher: Springer Science and Business Media Deutschland GmbH
DOI: 10.1186/s13244-021-01105-3

Explainable AI for automated respiratory misalignment detection in PET/CT imaging

Author(s): Yazdan Salimi, Zahra Mansouri, Mehdi Amini, Ismini Mainta, Habib Zaidi
Published in: Physics in Medicine & Biology, Issue 69, 2024, ISSN 0031-9155
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6560/ad8857

Joint EURADOS-EANM initiative for an advanced computational framework for the assessment of external dose rates from nuclear medicine patients

Author(s): Lara Struelens, Christelle Huet, David Broggio, Jérémie Dabin, Laurent Desorgher, Augusto Giussani, Wei Bo Li, Dietmar Nosske, Yi-Kang Lee, Lidia Cunha, Maria J. R. Carapinha, Mario Medvedec, Peter Covens
Published in: EJNMMI Physics, Issue 11, 2024, ISSN 2197-7364
Publisher: Springer Verlag
DOI: 10.1186/s40658-024-00638-y

The role of biomarkers and dosimetry parameters in overall and progression free survival prediction for patients treated with personalized 90Y glass microspheres SIRT: a preliminary machine learning study

Author(s): Zahra Mansouri, Yazdan Salimi, Ghasem Hajianfar, Nicola Bianchetto Wolf, Luisa Knappe, Genti Xhepa, Adrien Gleyzolle, Alexis Ricoeur, Valentina Garibotto, Ismini Mainta, Habib Zaidi
Published in: European Journal of Nuclear Medicine and Molecular Imaging, 2024, ISSN 1619-7070
Publisher: Springer Verlag
DOI: 10.1007/s00259-024-06805-8

Enhancing precision: A predictive model for ¹⁷⁷Lu-DOTATATE treatment response in neuroendocrine tumors using quantitative ⁶⁸Ga-DOTATATE PET and clinicopathological biomarkers

Author(s): Azadeh Akhavanallaf, Sonal Joshi, Arathi Mohan, Francis P Worden, John C Krauss, Habib Zaidi, Kirk Frey, Krithika Suresh, Yuni K Dewaraja, Ka Kit Wong
Published in: Theranostics, Issue 14, 2024, Page(s) 3708-3718, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.98053

Effect of Spectral Filtering and Segmental X-ray Tube Current Switch-Off on Interventionalist’s Scatter Exposure during CT Fluoroscopy

Author(s): Oliver S. Grosser, Martin Volk, Marilena Georgiades, Daniel Punzet, Bahaa Alsawalhi, Dennis Kupitz, Jazan Omari, Heiko Wissel, Michael C. Kreissl, Georg Rose, Maciej Pech
Published in: Bioengineering, Issue 11, 2024, Page(s) 838, ISSN 2306-5354
Publisher: MDPI
DOI: 10.3390/bioengineering11080838

Determining Out-of-Field Doses and Second Cancer Risk From Proton Therapy in Young Patients—An Overview

Author(s): Romero-Expósito M, Toma-Dasu I, Dasu A
Published in: Frontiers in Oncology, Issue 2022 May 31;12:892078, 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.892078

Fully automated accurate patient positioning in computed tomography using anterior–posterior localizer images and a deep neural network: a dual-center study

Author(s): Yazdan Salimi; Isaac Shiri; Azadeh Akavanallaf; Zahra Mansouri; Hossein Arabi; Habib Zaidi
Published in: European Radiology 2023, Issue 2023 May;33(5), 2023, Page(s) 3243-3252, ISSN 1432-1084
Publisher: Springer
DOI: 10.1007/s00330-023-09424-3

Occupational radiation exposure assessment during the management of [68Ga]Ga-DOTA-TOC

Author(s): Riveira-Martin M, Struelens L, Schoonjans W, Sánchez-Díaz I, Muñoz Iglesias J, Ferreira Dávila Ó, Salvador Gómez FJ, Salgado Fernández M, López Medina A
Published in: EJNMMI Physics, Issue 9, 75 (2022), 2022, ISSN 2197-7364
Publisher: Springer
DOI: 10.1186/s40658-022-00505-8

Influence of X-ray spectrum and bowtie filter characterisation on the accuracy of Monte Carlo simulated organ doses: Validation in a whole-body CT scanning mode

Author(s): Gwenny Verfaillie, Jeff Rutten, Lore Dewulf, Yves D’Asseler, Klaus Bacher
Published in: Physica Medica, Issue 127, 2024, Page(s) 104837, ISSN 1120-1797
Publisher: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2024.104837

Predictive value of 99mTc-MAA-based dosimetry in personalized 90Y-SIRT planning for liver malignancies

Author(s): Mercedes Riveira-Martin; Azadeh Akhavanallaf; Zahra Mansouri; Nicola Bianchetto Wolf; Yazdan Salimi; Alexis Ricoeur; Ismini Mainta; Valentina Garibotto; Antonio López Medina; Habib Zaidi
Published in: EJNMMI research, Issue vol. 13, no. 1 (2023) 63, 2023, ISSN 2191-219X
Publisher: Springer Berlin
DOI: 10.1186/s13550-023-01011-3

Digital phantom versus patient‐specific radiation dosimetry in adult routine thorax CT examinations

Author(s): Antonios E. Papadakis, Vassiliki Giannakaki, John Stratakis, Marios Myronakis, Habib Zaidi, John Damilakis
Published in: Journal of Applied Clinical Medical Physics, Issue 25, 2024, ISSN 1526-9914
Publisher: American Institute of Physics
DOI: 10.1002/acm2.14389

Object and person tracking systems to enable extremity dosimetry in nuclear medicine using computational methods

Author(s): Daniel Santiago Rondón, Pasquale Lombardo, Mahmoud Abdelrahman, Lara Struelens, Filip Vanhavere, Niki Bergans
Published in: Journal of Radiological Protection, Issue 44, 2024, Page(s) 021524, ISSN 0952-4746
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6498/ad53d5

The predictive value of pretherapy [ 68Ga]Ga‑DOTA‑TATE PET and biomarkers in [ 177Lu]Lu‑PRRT tumor dosimetry

Author(s): Habib Zaidi
Published in: Eur J Nucl Med Mol Imaging, Issue 50, 2023, Page(s) 2984–2996 (2023), ISSN 1619-7070
Publisher: Springer Verlag
DOI: 10.1007/s00259-023-06252-x

An efficient dual-domain deep learning network for sparse-view CT reconstruction

Author(s): Chang Sun, Yazdan Salimi, Neroladaki Angeliki, Sana Boudabbous, Habib Zaidi
Published in: Computer Methods and Programs in Biomedicine, Issue 256, 2024, Page(s) 108376, ISSN 0169-2607
Publisher: Elsevier BV
DOI: 10.1016/j.cmpb.2024.108376

Deep Learning-based calculation of patient size and attenuation surrogates from localizer Image: Toward personalized chest CT protocol optimization

Author(s): Salimi Y, Shiri I, Akhavanallaf A, Mansouri Z, Sanaat A, Pakbin M, Ghasemian M, Arabi H, Zaidi H
Published in: European Journal of Radiology, Issue Volume 157, 110602, 2022, ISSN 0720-048X
Publisher: Elsevier BV
DOI: 10.1016/j.ejrad.2022.110602

Thesis and dissertations (2)

Dosimetría personalizada a trabajadores y pacientes en procedimientos de Medicina Nuclear con nuevos radiofármacos teranósticos

Author(s): Mercedes del Carmen Riveira Martín
Published in: 2024
Publisher: Universidad Complutense de Madrid, Facultad de Medicina

Strategies for radiation dose calculation and optimization in diagnostic and therapeutic nuclear medicine procedure

Author(s): Akhavanallaf A
Published in: 2023
Publisher: UNIGE
DOI: 10.13097/archive-ouverte/unige:168338

Conference proceedings (4)

Real-time voxelwise patient-specific Monte Carlo dose reconstruction in whole-body CT scan images using deep neural network

Author(s): Salimi Y, Akhavanallaf A, Mansouri Z, Shiri I, Zaidi H
Published in: IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2022
Publisher: IEEE

Fully automated multi-organ segmentation in CT images via deep neural networks

Author(s): Salimi Y, Shiri I, Mansouri Z, Zaidi H
Published in: IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2022
Publisher: IEEE

Head and neck cancer overall survival prognostication using dosiomics features and random survival Forest algorithm

Author(s): Mansouri Z, Salimi Y, Amini M, Hajianfar G, Oveisi M, Shiri I, Zaidi H
Published in: IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2022
Publisher: IEEE

Advancing continuous education in the radiology department: case example through a novel software that quantifies repeated scans in CT

Author(s): Niki Fitousi, Tom Van Herpe, Bojan Arnaudovski, Thomas De Waelheyns, Hilde Bosmans, Jurgen Jacobs
Published in: Proceedings of the European Radiation Protection Week 2022, 2022
Publisher: Centro de Ciências e Tecnologias Nucleares