Evidence about the impact of urban interventions on mental health and wellbeing is scarce. Cities are complex systems and, thus, it is hard to infer causal associations within the system. Research to explore the links between urban systems with health requires more robust and interdisciplinary research. In the project we developed a novel conceptual and methodological geoemotional approach. We aim to analyse and measure, from a psychophysiological perspective, how people respond to urban stimuli combining biosensing, neuroscience, urban analytics, and surveys. Hence, the expected outcomes will provide insights into how urban built environments impact people’s mood, lifestyle, work, travelling and, ultimately, mental health and well-being. By integrating neuroscience knowledge and tools to facilitate a deeper understanding of the underlying biological and psychological processes, our research will provide mechanistic evidence on how to create urban environments to promote healthy living. At the same time, it will provide robust knowledge to empower European and global communities for tackling contemporary challenges, such as climate change, air and noise pollution, as well as social inequities on access to (mental) health care. From an economical perspective, our approach can be adopted (with potential high impact and job creation) across different markets, such as the real estate market, geodemographics and marketing companies, urban analytics and geospatial intelligence. Another societal implication of the project will be our Spatial Data Infrastructure. Built in line with the recommendations of best practices from the Open Geospatial Consortium and following the data FAIR principles, it promotes the access to data and knowledge, empower citizens and policymakers as well. The richness of our heterogenous dataset will leverage the development of new tools for scientific interrogation and could be very powerful for adopting largescale collaborative datasets. Furthermore, it will also allow the post-project dissemination of the project conceptual framework, through subsequent cross-disciplinary collaborations between geospatial and neuroscience research groups worldwide. Moreover, we have developed a “emotional walker” wearable kit that allows us to collect georeferenced microclimate and human-level psychophysiological data. The fusion of these physiological features and self-reporting tools for mental state assessment, with state-of-the-art AI models, will allow us to derive a deep interpretation of the human (brain) and environment interaction. Preliminary results dissemination have caught the attention of local and national stakeholders, international organizations in various fields (of architecture, construction, real state and urban development) and academia.