Project description
Metabolic imaging for better diagnosis and treatment in osteoarthritis
Osteoarthritis (OA) is a form of progressive arthritis, affecting at least 10 % of the European population. It degrades synovial joints in hands, knees, hips and spine, leading to stiffness, severe pains and disability. Early detection and evaluation of OA’s course is crucial for efficient treatment. However, conventional X-rays or MRI scans are used that offer limited information on tissues’ clinical picture. For this reason, the EU-funded METAJOINT project aims to introduce an innovative evaluation method: metabolic imaging for joint disease. It is based on MRI-enabled visualisation of specific elements’ (sodium, phosphorus, deuterium) distribution. This will allow to identify special tissues’ turnover and metabolic aspects of joints and will enable accurate prediction of the disease, proper medication treatment and better guidance for patients.
Objective
Osteoarthritis is a painful and disabling life-altering joint disease and the most common form of disability in our society. There are very limited treatment options for osteoarthritis and in most cases, osteoarthritis is slowly progressive, sometimes over a period of decades. More than 10% of entire the population in Europe has osteoarthritis in knee, hip or hands that leads to disability, pain and limited quality of life. In the METAJOINT study we propose to test new metabolic imaging methods of joint disease using MRI that can visualize the distribution of specific elements such as sodium, phosphorus and deuterium. As these elements are taken up in the tissue dependent on disease characteristics, the method can identify tissue turnover or metabolic aspects of the diseased or healthy joint, whereas conventional MRI detects hydrogen protons that provide only the amount of tissue such as cartilage thickness or volume. The aim of METAJOINT concerns the scanning of a limited set of a total of 15 patients for three imaging methods to scan for respectively phosphorus, sodium and deuterium, showing - for the first time – subchondral bone turnover through uptake of bisphosphonates, sodium retention in cartilage in patients with high salt concentration, and glycosaminoglycan turnover in cartilage through uptake of heavy water. This new ground-breaking evaluation method for joint disease will help pharmaceutical companies with better outcome measures in order to find disease modifying medication that can treat osteoarthritis and it can be used by physicians and surgeons for early detection of osteoarthritis and early prediction of the course of the disease, which helps to better guide patients with early or late phase osteoarthritis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences chemical sciences inorganic chemistry alkali metals
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET)
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.2.1. - FET Open
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
CSA - Coordination and support action
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-FETOPEN-2018-2020
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3584 CX Utrecht
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.