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Genetic Architecture Of Sex Steroid-related Psychiatric Disorders

Project description

A closer look at how sex hormones impact mental health

There is a connection between sex hormones and mental health. The EU-funded GASSP project will investigate the interplay between gender, sex and mental states. Specifically, it will study whether genetic and environmental markers can help identify women at risk of psychiatric disorders in relation to the menstrual cycle, childbirth and transition to menopause. The project is the first molecular genetic study of psychiatric sensitivity to sex hormone changes. The findings will improve the current approach to diagnosis, prevention and treatment. By providing evidence-based, easy-to-understand information, GASSP will contribute to the de-stigmatisation of mental disorders related to women’s reproduction.

Objective

Psychiatric disorders associated with changes in female sex hormones are a major public health issue and represent a unique opportunity to study the complex interplay between gender, sex and mental states. GASSP aims to understand how genetic and environmental markers can help identify women at risk of psychiatric disorders in relation to the menstrual cycle, childbirth and transition to menopause and improve the current approach to diagnosis, prevention and treatment. It takes a ground-breaking approach across diagnoses and life stages, rather than focussing on the current diagnostic labels that have limited clinical and biological validity. It seeks to characterise the largest cohort to date of women with psychiatric disorders temporally related with changes in sex hormones by leveraging new technologies a) to identify and reach sufferers, making it easier for them to participate in research b) to conduct sophisticated analyses, integrating detailed longitudinal clinical and psycho-social information with aggregated genome-wide data and functional annotations. GASSP is the first molecular genetic study of the psychiatric sensitivity to sex hormone changes. It has the potential to contribute to the de-stigmatization of mental disorders related to female reproduction by providing evidence-based, easy-to-understand information to the public, and addressing the gender gap in psychiatry highlighted by the European Commission and the World Health Organization.

Fields of science (EuroSciVoc)

Keywords

Programme(s)

Topic(s)

Funding Scheme

ERC-STG - Starting Grant

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Call for proposal

(opens in new window) ERC-2020-STG

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Host institution

CARDIFF UNIVERSITY
Net EU contribution
€ 1 499 961,00
Address
RESEARCH SERVICES C/O MAIN BUILDING
CF10 3AT CARDIFF
United Kingdom
Region
Wales East Wales Cardiff and Vale of Glamorgan
Activity type
Higher or Secondary Education Establishments
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Total cost
€ 1 499 961,00

Beneficiaries (1)