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Deciphering the network of microbial, environmental and physical factors underlying aggregation and enhanced performance in syntrophic microorganism communities

Project description

Who is in or out and why in microbial communes

Many applications relying on microorganisms utilise more than just one. Microbial communities tend to boost each other’s potential in mutually supportive ways. In syntrophic communities, two or more metabolically different species exchange metabolites to keep the overall metabolic machinery of all species running smoothly. Like a clinician who helps us understand why supplements should be taken in combination with certain nutrients to enhance absorption, we need to better understand why certain microbes aggregate so we can ensure optimal cultures that boost productivity. The EU-funded SYNAG project is out to identify the many interrelated factors guiding the formation of optimal partnerships among syntrophic communities to enhance the production of methane in sustainable energy applications.

Objective

Syntrophic microorganisms perform unique and crucial tasks in microbial processes used for sustainable energy (methane) and nutrient recovery from various organic waste streams. These syntrophic microorganisms cooperate to metabolically degrade acids but there are barriers and challenges to these organisms reaching their full potential, which restricts productivity and stability in the biomethane process. The cooperative lifestyle and cultivation of syntrophic microorganisms strongly points towards linkage between syntrophic cell aggregation (SYNAG) and acid-degrading activities that open up opportunities for biotechnology strategies. In this project, I will provide fundamental understanding of environmental, microbial, and physical effects on cell aggregating activities in syntrophic communities. To do so, I will take advantage of a unique collection of syntrophic cultures obtained through extensive research. Firstly, I will unravel mechanisms used for aggregation by comparing the transcriptional profiles of syntrophic cultures and develop molecular analyses to quantify aggregating activities. The second part of the project will focus on development of a cultivation system and in-situ detection that will maintain the complex syntrophic interactions intact. These methods will be combined for parallel analyses of cell aggregation in syntrophic communities and their responses in to a wide spectrum of factors with relevance to anaerobic processes. Aggregating activities will further be linked to effects on acid degradation rates and resistance of the microbial community towards stress. In the final part of the project, factors that enhance aggregating activities will be assessed in systems that mimic the real situation in anaerobic systems. SYNAG will thus provide fundamental understanding of syntrophic ecology and physiology that will be highly valuable in anaerobic techniques that has great expansion potential in future work of building biomass based platforms.

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Topic(s)

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Funding Scheme

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ERC-STG - Starting Grant

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Call for proposal

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(opens in new window) ERC-2020-STG

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Host institution

SVERIGES LANTBRUKSUNIVERSITET
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 992 622,00
Address
ALMAS ALLE 8
750 07 Uppsala
Sweden

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Region
Östra Sverige Östra Mellansverige Uppsala län
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 992 622,00

Beneficiaries (1)

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