Evolution of pro- and eukaryotic commensals within the human gut

Información del proyecto

EPYC

Identificador del acuerdo de subvención: 948219

DOI

10.3030/948219

Fecha de la firma de la CE 20 Enero 2021

Fecha de inicio 1 Febrero 2021

Fecha de finalización 31 Julio 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 499 993,00

Aportación de la UE

€ 1 499 993,00

Coordinado por

QUADRAM INSTITUTE BIOSCIENCE
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management Plan (DMP)

Data Management Plan DMP

Publicaciones

Peer reviewed articles (27)

Structure and function of the soil microbiome underlying N2O emissions from global wetlands

Autores: Mohammad Bahram, Mikk Espenberg, Jaan Pärn, Laura Lehtovirta-Morley, Sten Anslan, Kuno Kasak, Urmas Kõljalg, Jaan Liira, Martin Maddison, Mari Moora, Ülo Niinemets, Maarja Öpik, Meelis Pärtel, Kaido Soosaar, Martin Zobel, Falk Hildebrand, Leho Tedersoo, Ülo Mander
Publicado en: Nature Communications, Edición 20411723, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-29161-3

adhesiomeR: a tool for Escherichia coli adhesin classification and analysis

Autores: Katarzyna Sidorczuk, Michał Burdukiewicz, Klara Cerk, Joachim Fritscher, Robert A. Kingsley, Peter Schierack, Falk Hildebrand, Rafał Kolenda
Publicado en: BMC Genomics, Edición 25, 2024, ISSN 1471-2164
Editor: BioMed Central
DOI: 10.1186/s12864-024-10525-6

Microbiota Dysbiosis and Gut Barrier Dysfunction Associated with Non-Alcoholic Fatty Liver Disease Are Modulated by a Specific Metabolic Cofactors’ Combination

Autores: Sergio Quesada-Vázquez; Caitlin Bone; Shikha Saha; Iris Triguero; Marina Colom-Pellicer; Gerard Aragonès; Falk Hildebrand; Josep M. del Bas; Antoni Caimari; Naiara Beraza; Xavier Escoté
Publicado en: International Journal of Molecular Sciences, Edición 1, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232213675

Dispersal strategies shape persistence and evolution of human gut bacteria

Autores: Falk Hildebrand, Toni I. Gossmann, Clemence Frioux, Ezgi Ozkurt, Pernille Neve Myers, Pamela Ferretti, Michael Kuhn, Mohammad Bahram, Henrik Bjørn Nielsen, Peer Bork
Publicado en: Cell Host & Microbe, Edición 19313128, 2021, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2021.05.008

KSGP 3.1: improved taxonomic annotation of Archaea communities using LotuS2, the genome taxonomy database and RNAseq data

Autores: Alastair Grant, Abdullah Aleidan, Charli S Davies, Solomon C Udochi, Joachim Fritscher, Mohammad Bahram, Falk Hildebrand
Publicado en: ISME Communications, Edición 5, 2025, ISSN 2730-6151
Editor: Oxford University Press (OUP)
DOI: 10.1093/ismeco/ycaf094

Regulation of intestinal senescence during cholestatic liver disease modulates barrier function and liver disease progression

Autores: Mar Moreno-Gonzalez, Katherine Hampton, Paula Ruiz, Gemma Beasy, Falk SP. Nagies, Aimee Parker, James Lazenby, Caitlin Bone, Ane Alava-Arteaga, Meha Patel, Charlotte Hellmich, Pablo Luri-Martin, Ece Silan, Mark Philo, David Baker, Simon M. Rushbrook, Falk Hildebrand, Stuart A. Rushworth, Naiara Beraza
Publicado en: JHEP Reports, Edición 6, 2024, Página(s) 101159, ISSN 2589-5559
Editor: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101159

Gut microbiota dysbiosis in Parkinson disease: A systematic review and pooled analysis

Autores: Sven Kleine Bardenhorst; Emanuele Cereda; Marco Severgnini; Michela Barichella; Gianni Pezzoli; Ali Keshavarzian; Alessandro Desideri; Daniele Pietrucci; Velma T. E. Aho; Filip Scheperjans; Falk Hildebrand; Severin Weis; Markus Egert; André Karch; Marius Vital; Nicole Rübsamen
Publicado en: European Journal of Neurology, Edición 1, 2023, ISSN 1468-1331
Editor: Wiley
DOI: 10.1111/ene.15671

Global functional spectrum of soil bacterial communities

Autores: Gabin Piton; Steven Allison; Mohammad Bahram; Falk Hildebrand; Jennifer Martiny; Kathleen K. Treseder; Adam Martiny
Publicado en: Nature Microbiology, Edición 2, 2023, ISSN 2058-5276
Editor: Spring Nature
DOI: 10.1038/s41564-023-01465-0

LotuS2: an ultrafast and highly accurate tool for amplicon sequencing analysis

Autores: Ezgi Özkurt, Joachim Fritscher, Nicola Soranzo, Duncan Y. K. Ng, Robert P. Davey, Mohammad Bahram, Falk Hildebrand
Publicado en: BMC Microbiome, Edición 20492618, 2022, ISSN 2049-2618
Editor: Springer Nature
DOI: 10.1186/s40168-022-01365-1

Enrichment of gut microbiome strains for cultivation-free genome sequencing using droplet microfluidics

Autores: Anna Pryszlak; Tobias Wenzel; Kiley West Seitz; Falk Hildebrand; Ece Kartal; Marco Raffaele Cosenza; Vladimir Benes; Peer Bork; Christoph A. Merten
Publicado en: Cell Reports Methods, Edición 26672375, 2022, ISSN 2667-2375
Editor: Cell Press
DOI: 10.1016/j.crmeth.2021.100137

Glacier melt-down changes habitat characteristics and unique microbial community composition and physiology in alpine lake sediments

Autores: Julia Kleinteich, Kurt Hanselmann, Falk Hildebrand, Andreas Kappler, Christiane Zarfl
Publicado en: FEMS Microbiology Ecology, Edición 01686496, 2022, ISSN 0168-6496
Editor: Blackwell
DOI: 10.1093/femsec/fiac075

Pervasive associations between dark septate endophytic fungi with tree root and soil microbiomes across Europe

Autores: Tarquin Netherway, Jan Bengtsson, Franz Buegger, Joachim Fritscher, Jane Oja, Karin Pritsch, Falk Hildebrand, Eveline J. Krab, Mohammad Bahram
Publicado en: Nature Communications, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-44172-4

Benchmark of Data Processing Methods and Machine Learning Models for Gut Microbiome-Based Diagnosis of Inflammatory Bowel Disease

Autores: Ryszard Kubinski, Jean-Yves Djamen-Kepaou, Timur Zhanabaev, Alex Hernandez-Garcia, Stefan Bauer, Falk Hildebrand, Tamas Korcsmaros, Sani Karam, Prévost Jantchou, Kamran Kafi, Ryan D. Martin
Publicado en: Frontiers in Genetics, Edición 16648021, 2022, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2022.784397

Population-level impacts of antibiotic usage on the human gut microbiome

Autores: Kihyun Lee, Sebastien Raguideau, Kimmo Sirén, Francesco Asnicar, Fabio Cumbo, Falk Hildebrand, Nicola Segata , Chang-Jun Cha, Christopher Quince
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-36633-7

Enterosignatures define common bacterial guilds in the human gut microbiome

Autores: Clemence Frioux, Rebecca Ansorge, Ezgi Ozkurt, Chabname Ghassemi Nedjad, Joachim Fritscher, Christopher Quince, Sebastian M. Waszak, Falk Hildebrand
Publicado en: Cell Host & Microbe, 2023, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2023.05.024

A prebiotic dietary pilot intervention restores faecal metabolites and may be neuroprotective in Parkinson’s Disease

Autores: Janis Rebecca Bedarf, Stefano Romano, Silke Sophie Heinzmann, Anthony Duncan, Maria H. Traka, Duncan Ng, Daniella Segovia-Lizano, Marie-Christine Simon, Arjan Narbad, Ullrich Wüllner, Falk Hildebrand
Publicado en: npj Parkinson's Disease, Edición 11, 2025, Página(s) npj Parkinson's Disease, ISSN 2373-8057
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41531-025-00885-5

Ecological insights into the microbiology of food using metagenomics and its potential surveillance applications

Autores: Samuel J. Bloomfield, Falk Hildebrand, Aldert L. Zomer, Raphaëlle Palau, Alison E. Mather
Publicado en: Microbial Genomics, Edición 11, 2025, ISSN 2057-5858
Editor: Microbiology Society
DOI: 10.1099/mgen.0.001337

A single dietary factor, daily consumption of a fermented beverage, can modulate the gut microbiome within the same ethnic community

Autores: Santanu Das; Ezgi Özkurt; Tulsi Kumari Joishy; Dibyayan Deb; Ashis K. Mukherjee; Falk Hildebrand; Mojibur R. Khan
Publicado en: mSystems, Edición 1, 2023, ISSN 2379-5077
Editor: ASM
DOI: 10.1101/2023.01.18.524612

Reply to: Microbial dark matter could add uncertainties to metagenomic trait estimations

Autores: Gabin Piton, Steven D. Allison, Mohammad Bahram, Falk Hildebrand, Jennifer B. H. Martiny, Kathleen K. Treseder, Adam C. Martiny
Publicado en: Nature Microbiology, Edición 9, 2024, Página(s) 1431-1433, ISSN 2058-5276
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41564-024-01688-9

IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis

Autores: Dominic Denk, Mallika Ramakrishnan, Claire Conche, Charles Pallangyo, Marina Pesic, Fatih Ceteci, Kilian B. Kennel, Asude C. Kirisözü, Esther Engel, Kathleen Mohs, Birgit Ritter, Angeles Macias Pardo, Ezgi Özkurt, Falk Hildebrand, Ari Waisman, Melek C. Arkan, Florian R. Greten
Publicado en: Immunity, Edición 58, 2025, Página(s) 701-715.e8, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2025.02.005

A single dietary factor, daily consumption of a fermented beverage, can modulate the gut bacteria and fecal metabolites within the same ethnic community

Autores: Santanu Das, Ezgi Özkurt, Tulsi Kumari Joishy, Ashis K. Mukherjee, Falk Hildebrand, Mojibur R. Khan
Publicado en: mSystems, Edición 8, 2024, ISSN 2379-5077
Editor: American Society for Microbiology
DOI: 10.1128/msystems.00745-23

Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity

Autores: Sergio Quesada-Vazquez Anna Castells-Nobau, Jessica Latorre, Nuria Oliveras-Canellas, Irene Puig-Parnau, Noemi Tejera, Yaiza Tobajas, Julio Baudin, Falk Hildebrand, Naiara Beraza, Remy Burcelin, Laura Martinez-Gili, Julien Chilloux, Marc-Emmanuel Dumas, Massimo Federici,Lesley Hoyles, Antoni Caimari, Josep M. del Bas, Xavier Escote, Jose-Manuel Fernandez-Real
Publicado en: Cell Reports Medicine, 2023, ISSN 2666-3791
Editor: Elsevier
DOI: 10.1016/j.xcrm.2023.101341

Microbial composition and dynamics in environmental samples from a ready-to-eat food production facility with a long-term colonisation of Listeria monocytogenes

Autores: Diaz Maria, Heather Aird, Thanh Le Viet, Ana Victoria Gutierrez, Nasmille Larke-Mejia, Oleksii Omelchenko, Lluis Moragues-Solanas, Joachim Fritscher, Nicolle Som, Jim McLauchlin, Falk Hildebrand, Frieda Jørgensen, Matthew Gilmour
Publicado en: Food Microbiology, 2024, ISSN 0740-0020
Editor: Academic Press
DOI: 10.21203/rs.3.rs-3910281/v1

Community‐scale models of microbiomes: Articulating metabolic modelling and metagenome sequencing

Autores: Klara Cerk; Pablo Ugalde‐Salas; Chabname Ghassemi Nedjad; Maxime Lecomte; Coralie Muller; David J. Sherman; Falk Hildebrand; Simon Labarthe; Clémence Frioux
Publicado en: Microbial Biotechnology, 2024, ISSN 1751-7915
Editor: Wiley
DOI: 10.1111/1751-7915.14396

Ultra-resolution Metagenomics: When Enough Is Not Enough.

Autores: Falk Hildebrand
Publicado en: mSystems, Edición 00219193, 2022, ISSN 0021-9193
Editor: American Society for Microbiology
DOI: 10.1128/msystems.00881-21

Metagenomic analyses of gut microbiome composition and function with age in a wild bird; little change, except increased transposase gene abundance

Autores: Chuen Zhang Lee, Sarah F Worsley, Charli S Davies, Ece Silan, Terry Burke, Jan Komdeur, Falk Hildebrand, Hannah L Dugdale, David S Richardson
Publicado en: ISME Communications, Edición 5, 2025, ISSN 2730-6151
Editor: Oxford University Press (OUP)
DOI: 10.1093/ismeco/ycaf008

Genomic evidence of symbiotic adaptations in fungus-associated bacteria

Autores: Daniyal Gohar, Kadri Põldmaa, Mari Pent, Saleh Rahimlou, Klara Cerk, Duncan Y.K. Ng, Falk Hildebrand, Mo Bahram
Publicado en: iScience, Edición 28, 2025, Página(s) 112253, ISSN 2589-0042
Editor: Elsevier BV
DOI: 10.1016/j.isci.2025.112253