Re-defining clinical care and reasoning in ST-elevation myocardial infarction (STEMI) by shifting focus to ischemic myocardial stunning - Mechanisms prognostic implications and a new treatment

Project Information

De-StunHeartAttacks

Grant agreement ID: 948665

DOI

10.3030/948665

EC signature date 27 October 2020

Start date 1 November 2020

End date 30 April 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

GOETEBORGS UNIVERSITET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Comparison of the proteomic landscape in experimental ischemia reperfusion with versus without ischemic preconditioning

Author(s): Yalda Kakaei, Shafaat Hussain, Ahmed Elmahdy, Evelin Berger, Aaron Shekka Espinosa, Valentyna Sevastianova, Zahra Sheybani, Amin Al-Awar, Mana Kalani, Sandeep Jha, Ermir Zulfaj, Amirali Nejat, Abhishek Jha, Tetiana Pylova, Maryna Krasnikova, Erik Axel Andersson, Vagner Ramon Rodrigues Silva, Elmir Omerovic, Björn Redfors
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-025-90735-4

Prospective comparison of temporal changes in myocardial function in women with Takotsubo versus anterior STEMI

Author(s): Sandeep Jha, Angela Poller, Aaron Shekka Espinosa, Linnea Molander, Valentyna Sevastianova, Rickard Zeijlon, Koen Simons, Emanuele Bobbio, Carlo Pirazzi, Andreas Martinsson, Tomas Mellberg, Thorsteinn Gudmundsson, Petronella Torild, Joakim Sundstrom, Erik Axel Andersson, Sigurdur Thorleifsson, Sabin Salahuddin, Ahmed Elmahdy, Tetiana Pylova, Araz Rawshani, Oskar Angeras, Truls Ramunddal, Kristofer
Published in: Clinical Research in Cardiology, 2025, ISSN 1861-0684
Publisher: Steinkopff
DOI: 10.1007/s00392-025-02633-4

Associations between female sex hormones, estrous cycle, ischemic preconditioning and myocardial infarct size after ischemia–reperfusion injury

Author(s): Tetiana Pylova, Ahmed Elmahdy, Maryna Krasnikova, Abhishek Jha, Erik Axel Andersson, Yalda Kakaei, Aaron Shekka Espinosa, Amin Al-Awar, Ermir Zulfaj, Amirali Nejat, Valentyna Sevastianova, Mana Kalani, Henrik Ryberg, Åsa Tivesten, Elmir Omerovic, Björn Redfors
Published in: Basic Research in Cardiology, Issue 120, 2025, Page(s) 321-333, ISSN 1435-1803
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00395-025-01099-9

Ischemic preconditioning affects phosphosites and accentuates myocardial stunning while reducing infarction size in rats

Author(s): Ahmed Elmahdy, Aaron Shekka Espinosa, Yalda Kakaei, Tetiana Pylova, Abhishek Jha, Ermir Zulfaj, Maryna Krasnikova, Amin Al-Awar, Zahra Sheybani, Valentyna Sevastianova, Evelin Berger, Amirali Nejat, Linnea Molander, Erik Axel Andersson, Elmir Omerovic, Shafaat Hussain, Björn Redfors
Published in: Frontiers in Cardiovascular Medicine, Issue 11, 2024, ISSN 2297-055X
Publisher: Frontiers Media SA
DOI: 10.3389/fcvm.2024.1376367

Comparative Analysis of Plasma Protein Dynamics in Women with ST-Elevation Myocardial Infarction and Takotsubo Syndrome

Author(s): Shafaat Hussain, Sandeep Jha, Evelin Berger, Linnea Molander, Valentyna Sevastianova, Zahra Sheybani, Aaron Shekka Espinosa, Ahmed Elmahdy, Amin Al-Awar, Yalda Kakaei, Mana Kalani, Ermir Zulfaj, Amirali Nejat, Abhishek Jha, Tetiana Pylova, Maryna Krasnikova, Erik Axel Andersson, Elmir Omerovic, Björn Redfors
Published in: Cells, Issue 13, 2025, Page(s) 1764, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells13211764

ECG differences and ECG predictors in patients presenting with ST segment elevation due to myocardial infarction versus takotsubo syndrome

Author(s): Rickard Zeijlon, Jasmina Chamat, Vina Le, Johan Wågerman, Israa Enabtawi, Sandeep Jha, Mohammed Munir Mohammed, Aaron Shekka Espinosa, Oskar Angerås, Truls Råmunddal, Elmir Omerovic, Björn Redfors
Published in: IJC Heart & Vasculature, 2022, ISSN 2352-9067
Publisher: Elsievier
DOI: 10.1016/j.ijcha.2022.101047

Prospective Comparison of Temporal Myocardial Function in Men Versus Women After Anterior ST-Elevation Myocardial Infarction With Timely Reperfusion

Author(s): Sandeep Jha, Aaron Shekka Espinosa, Linnea Molander, Angela Poller, Valentyna Sevastianova, Koen Simons, Julia Baranowska, Thorsteinn Gudmundsson, Emanuele Bobbio, Rickard Zeijlon, Carlo Pirazzi, Andreas Martinsson, Tomas Mellberg, Petronella Torild, Joakim Sundstrom, Erik Axel Andersson, Sigurdur Thorleifsson, Sabin Salahuddin, Ahmed Elmahdy, Tetiana Pylova, Oskar Angerås, Truls Ramunddal, Krist
Published in: The American Journal of Cardiology, Issue 244, 2025, Page(s) 48-57, ISSN 0002-9149
Publisher: Excerpta Medica, Inc.
DOI: 10.1016/j.amjcard.2025.02.015

Short‐ and Long‐Term Clinical Outcomes for Patients With Takotsubo Syndrome and Patients With Myocardial Infarction: A Report From the Swedish Coronary Angiography and Angioplasty Registry

Author(s): Björn Redfors, Sandeep Jha, Sigurdur Thorleifsson, Tomas Jernberg, Oskar Angerås, Ole Frobert, Petur Petursson, Per Tornvall, Giovanna Sarno, Christina Ekenbäck, Annika Ravn‐Fisher, Shams Y‐Hassan, Alexander R. Lyon, Stefan James, David Erlinge and Elmir Omerovic
Published in: Journal of the American Heart Association, 2021, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.119.017290

Inter- and intra-observer variability in the echocardiographic evaluation of wall motion abnormality in patients with ST-elevation myocardial infarction or Takotsubo syndrome – A novel approach

Author(s): Angela Poller, Sandeep Jha, Aaron Shekka Espinosa, Rickard Zeijlon, Sigurdur James Thorleifsson, Erik Axel Andersson, Emanuele Bobbio, Carlo Pirazzi, Thorsteinn Gudmundsson, Tomas Mellberg, Andreas Martinsson, Odd Bech-Hanssen, Björn Redfors
Published in: Echocardiography, 2023, ISSN 0742-2822
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/echo.15638

Differences between cardiac troponin I vs. T according to the duration of myocardial ischaemia

Author(s): Aaron Shekka Espinosa, Shafaat Hussain, Amin Al-Awar, Sandeep Jha, Ahmed Elmahdy, Mana Kalani, Yalda Kakei, Ermir Zulfaj, Emma Aune, Angela Poller, Emanuele Bobbio, Sigurdur Thoirleifsson, Rickard Zeijlon, Thorstein Gudmundursson, Mathias Wernbom, Bertil Lindahl, Christian L Polte, Elmir Omerovic, Ola Hammarsten, Björn Redfors
Published in: European Heart Journal Acute Cardiovascular Care, 2023, ISSN 2048-8726
Publisher: SAGE Publications Ltd
DOI: 10.1093/ehjacc/zuad017

Temporal electrocardiographic changes in anterior ST elevation myocardial infarction versus the Takotsubo syndrome

Author(s): Rickard Zeijlon, Sandeep Jha, Vina Le, Jasmina Chamat, Aaron Shekka Espinosa, Angela Poller, Sigurdur Thorleifsson, Emanuele Bobbi, Tomas Mellberg, Carlo Pirazzi, Thorsteinn Gudmundsson, Andreas Martinsson, Oskar Angerås, Truls Råmunddal, Elmir Omerovic, Björn Redfors
Published in: IJC Heart & Vasculature, 2023, ISSN 2352-9067
Publisher: Elsevier
DOI: 10.1016/j.ijcha.2023.101187

Risk of in-hospital life-threatening ventricular arrhythmia or death after ST-elevation myocardial infarction vs. the Takotsubo syndrome

Author(s): Rickard Zeijlon, Jasmina Chamat, Israa Enabtawi, Sandeep Jha, Mohammed Munir Mohammed, Johan Wågerman, Vina Le, Aaron Shekka Espinosa, Erik Nyman, Elmir Omerovic, Björn Redfors.
Published in: ESC Heart Failure, 2021, ISSN 2055-5822
Publisher: WIley
DOI: 10.1002/ehf2.13208

Thesis and dissertations (1)

Catching broken hearts - Electrocardiography and in-hospital outcome in Takotsubo syndrome versus ST elevation myocardial infarction

Author(s): Rickard Zeijlon
Published in: 2022, ISBN 9789180690270
Publisher: University of Gothenburg. Sahlgrenska Academy