Re-defining clinical care and reasoning in ST-elevation myocardial infarction (STEMI) by shifting focus to ischemic myocardial stunning - Mechanisms prognostic implications and a new treatment

Informations projet

De-StunHeartAttacks

N° de convention de subvention: 948665

DOI

10.3030/948665

Date de signature de la CE 27 Octobre 2020

Date de début 1 Novembre 2020

Date de fin 30 Avril 2026

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 1 500 000,00

Contribution de l’UE

€ 1 500 000,00

Coordonné par

GOETEBORGS UNIVERSITET
Sweden

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Publications

Peer reviewed articles (12)

Comparison of the proteomic landscape in experimental ischemia reperfusion with versus without ischemic preconditioning

Auteurs: Yalda Kakaei, Shafaat Hussain, Ahmed Elmahdy, Evelin Berger, Aaron Shekka Espinosa, Valentyna Sevastianova, Zahra Sheybani, Amin Al-Awar, Mana Kalani, Sandeep Jha, Ermir Zulfaj, Amirali Nejat, Abhishek Jha, Tetiana Pylova, Maryna Krasnikova, Erik Axel Andersson, Vagner Ramon Rodrigues Silva, Elmir Omerovic, Björn Redfors
Publié dans: Scientific Reports, Numéro 15, 2025, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-025-90735-4

Prospective comparison of temporal changes in myocardial function in women with Takotsubo versus anterior STEMI

Auteurs: Sandeep Jha, Angela Poller, Aaron Shekka Espinosa, Linnea Molander, Valentyna Sevastianova, Rickard Zeijlon, Koen Simons, Emanuele Bobbio, Carlo Pirazzi, Andreas Martinsson, Tomas Mellberg, Thorsteinn Gudmundsson, Petronella Torild, Joakim Sundstrom, Erik Axel Andersson, Sigurdur Thorleifsson, Sabin Salahuddin, Ahmed Elmahdy, Tetiana Pylova, Araz Rawshani, Oskar Angeras, Truls Ramunddal, Kristofer
Publié dans: Clinical Research in Cardiology, 2025, ISSN 1861-0684
Éditeur: Steinkopff
DOI: 10.1007/s00392-025-02633-4

Associations between female sex hormones, estrous cycle, ischemic preconditioning and myocardial infarct size after ischemia–reperfusion injury

Auteurs: Tetiana Pylova, Ahmed Elmahdy, Maryna Krasnikova, Abhishek Jha, Erik Axel Andersson, Yalda Kakaei, Aaron Shekka Espinosa, Amin Al-Awar, Ermir Zulfaj, Amirali Nejat, Valentyna Sevastianova, Mana Kalani, Henrik Ryberg, Åsa Tivesten, Elmir Omerovic, Björn Redfors
Publié dans: Basic Research in Cardiology, Numéro 120, 2025, Page(s) 321-333, ISSN 1435-1803
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s00395-025-01099-9

Ischemic preconditioning affects phosphosites and accentuates myocardial stunning while reducing infarction size in rats

Auteurs: Ahmed Elmahdy, Aaron Shekka Espinosa, Yalda Kakaei, Tetiana Pylova, Abhishek Jha, Ermir Zulfaj, Maryna Krasnikova, Amin Al-Awar, Zahra Sheybani, Valentyna Sevastianova, Evelin Berger, Amirali Nejat, Linnea Molander, Erik Axel Andersson, Elmir Omerovic, Shafaat Hussain, Björn Redfors
Publié dans: Frontiers in Cardiovascular Medicine, Numéro 11, 2024, ISSN 2297-055X
Éditeur: Frontiers Media SA
DOI: 10.3389/fcvm.2024.1376367

Comparative Analysis of Plasma Protein Dynamics in Women with ST-Elevation Myocardial Infarction and Takotsubo Syndrome

Auteurs: Shafaat Hussain, Sandeep Jha, Evelin Berger, Linnea Molander, Valentyna Sevastianova, Zahra Sheybani, Aaron Shekka Espinosa, Ahmed Elmahdy, Amin Al-Awar, Yalda Kakaei, Mana Kalani, Ermir Zulfaj, Amirali Nejat, Abhishek Jha, Tetiana Pylova, Maryna Krasnikova, Erik Axel Andersson, Elmir Omerovic, Björn Redfors
Publié dans: Cells, Numéro 13, 2025, Page(s) 1764, ISSN 2073-4409
Éditeur: MDPI AG
DOI: 10.3390/cells13211764

ECG differences and ECG predictors in patients presenting with ST segment elevation due to myocardial infarction versus takotsubo syndrome

Auteurs: Rickard Zeijlon, Jasmina Chamat, Vina Le, Johan Wågerman, Israa Enabtawi, Sandeep Jha, Mohammed Munir Mohammed, Aaron Shekka Espinosa, Oskar Angerås, Truls Råmunddal, Elmir Omerovic, Björn Redfors
Publié dans: IJC Heart & Vasculature, 2022, ISSN 2352-9067
Éditeur: Elsievier
DOI: 10.1016/j.ijcha.2022.101047

Prospective Comparison of Temporal Myocardial Function in Men Versus Women After Anterior ST-Elevation Myocardial Infarction With Timely Reperfusion

Auteurs: Sandeep Jha, Aaron Shekka Espinosa, Linnea Molander, Angela Poller, Valentyna Sevastianova, Koen Simons, Julia Baranowska, Thorsteinn Gudmundsson, Emanuele Bobbio, Rickard Zeijlon, Carlo Pirazzi, Andreas Martinsson, Tomas Mellberg, Petronella Torild, Joakim Sundstrom, Erik Axel Andersson, Sigurdur Thorleifsson, Sabin Salahuddin, Ahmed Elmahdy, Tetiana Pylova, Oskar Angerås, Truls Ramunddal, Krist
Publié dans: The American Journal of Cardiology, Numéro 244, 2025, Page(s) 48-57, ISSN 0002-9149
Éditeur: Excerpta Medica, Inc.
DOI: 10.1016/j.amjcard.2025.02.015

Short‐ and Long‐Term Clinical Outcomes for Patients With Takotsubo Syndrome and Patients With Myocardial Infarction: A Report From the Swedish Coronary Angiography and Angioplasty Registry

Auteurs: Björn Redfors, Sandeep Jha, Sigurdur Thorleifsson, Tomas Jernberg, Oskar Angerås, Ole Frobert, Petur Petursson, Per Tornvall, Giovanna Sarno, Christina Ekenbäck, Annika Ravn‐Fisher, Shams Y‐Hassan, Alexander R. Lyon, Stefan James, David Erlinge and Elmir Omerovic
Publié dans: Journal of the American Heart Association, 2021, ISSN 2047-9980
Éditeur: Wiley-Blackwell
DOI: 10.1161/jaha.119.017290

Inter- and intra-observer variability in the echocardiographic evaluation of wall motion abnormality in patients with ST-elevation myocardial infarction or Takotsubo syndrome – A novel approach

Auteurs: Angela Poller, Sandeep Jha, Aaron Shekka Espinosa, Rickard Zeijlon, Sigurdur James Thorleifsson, Erik Axel Andersson, Emanuele Bobbio, Carlo Pirazzi, Thorsteinn Gudmundsson, Tomas Mellberg, Andreas Martinsson, Odd Bech-Hanssen, Björn Redfors
Publié dans: Echocardiography, 2023, ISSN 0742-2822
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/echo.15638

Differences between cardiac troponin I vs. T according to the duration of myocardial ischaemia

Auteurs: Aaron Shekka Espinosa, Shafaat Hussain, Amin Al-Awar, Sandeep Jha, Ahmed Elmahdy, Mana Kalani, Yalda Kakei, Ermir Zulfaj, Emma Aune, Angela Poller, Emanuele Bobbio, Sigurdur Thoirleifsson, Rickard Zeijlon, Thorstein Gudmundursson, Mathias Wernbom, Bertil Lindahl, Christian L Polte, Elmir Omerovic, Ola Hammarsten, Björn Redfors
Publié dans: European Heart Journal Acute Cardiovascular Care, 2023, ISSN 2048-8726
Éditeur: SAGE Publications Ltd
DOI: 10.1093/ehjacc/zuad017

Temporal electrocardiographic changes in anterior ST elevation myocardial infarction versus the Takotsubo syndrome

Auteurs: Rickard Zeijlon, Sandeep Jha, Vina Le, Jasmina Chamat, Aaron Shekka Espinosa, Angela Poller, Sigurdur Thorleifsson, Emanuele Bobbi, Tomas Mellberg, Carlo Pirazzi, Thorsteinn Gudmundsson, Andreas Martinsson, Oskar Angerås, Truls Råmunddal, Elmir Omerovic, Björn Redfors
Publié dans: IJC Heart & Vasculature, 2023, ISSN 2352-9067
Éditeur: Elsevier
DOI: 10.1016/j.ijcha.2023.101187

Risk of in-hospital life-threatening ventricular arrhythmia or death after ST-elevation myocardial infarction vs. the Takotsubo syndrome

Auteurs: Rickard Zeijlon, Jasmina Chamat, Israa Enabtawi, Sandeep Jha, Mohammed Munir Mohammed, Johan Wågerman, Vina Le, Aaron Shekka Espinosa, Erik Nyman, Elmir Omerovic, Björn Redfors.
Publié dans: ESC Heart Failure, 2021, ISSN 2055-5822
Éditeur: WIley
DOI: 10.1002/ehf2.13208

Thesis and dissertations (1)

Catching broken hearts - Electrocardiography and in-hospital outcome in Takotsubo syndrome versus ST elevation myocardial infarction

Auteurs: Rickard Zeijlon
Publié dans: 2022, ISBN 9789180690270
Éditeur: University of Gothenburg. Sahlgrenska Academy