Hyperpolarized ultra-low field (ULF) magnetic resonance to design next generation functional contrast agents

Project Information

HyperULFNMR

Grant agreement ID: 949180

DOI

10.3030/949180

Project closed

EC signature date 29 July 2020

Start date 1 January 2021

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Hyperpolarized Multi-organ Spectroscopy of Liver and Brain Using 1-C-13-Pyruvate Enhanced via Parahydrogen

Author(s): Theresa L. K. Hune; Salvatore Mamone; Andreas B. Schmidt; Inês Mahú; Natascha D’Apolito; Dirk Wiedermann; Jens Brüning; Stefan Glöggler
Published in: Applied Magnetic Resonance, Issue 2, 2023, Page(s) 1283-1295, ISSN 0937-9347
Publisher: Springer Verlag
DOI: 10.1007/s00723-023-01578-z

Assessing a hyperpolarized [1-13C]-labeled alanine derivative enhanced via parahydrogen for in vivo studies

Author(s): Lisa M. Fries, Denis Moll, Ruhuai Mei, Theresa L․ K․ Hune, Josef Elsaßer, Stefan Glöggler
Published in: Journal of Magnetic Resonance Open, Issue 22, 2025, Page(s) 100183, ISSN 2666-4410
Publisher: Elsevier BV
DOI: 10.1016/j.jmro.2024.100183

Real-Time Pyruvate Chemical Conversion Monitoring Enabled by PHIP

Author(s): Gabriele Stevanato; Yonghong Ding; Salvatore Mamone; Anil P. Jagtap; Sergey Korchak; Stefan Glöggler
Published in: Journal of the American Chemical Society, Issue 145(10), 2023, Page(s) 5864-5871, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c13198

Molecular precursors to produce para‐hydrogen enhanced metabolites at any field

Author(s): Anil P. Jagtap; Salvatore Mamone; Stefan Glöggler
Published in: Magnetic Resonance in Chemistry, Issue 61(12), 2023, Page(s) 674-680, ISSN 0749-1581
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrc.5402

Hyperpolarization of ¹⁵N‐Pyridinium by Using Parahydrogen Enables Access to Reactive Oxygen Sensors and Pilot <i>In Vivo</i> Studies

Author(s): Ruhuai Mei, Lisa M. Fries, Theresa L. K. Hune, Maria Daniela Santi, Gonzalo Gabriel Rodriguez, Sonja Sternkopf, Stefan Glöggler
Published in: Angewandte Chemie International Edition, Issue 63, 2025, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202403144

A Field-Independent Method for the Rapid Generation of Hyperpolarized [1-13C]Pyruvate in Clean Water Solutions for Biomedical Applications

Author(s): Salvatore Mamone, Anil P. Jagtap, Sergey Korchak, Yonghong Ding, Sonja Sternkopf, Stefan Glöggler
Published in: Angewandte Chemie, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202206298

Bimodal Fluorescence/Magnetic Resonance Molecular Probes with Extended Spin Lifetimes

Author(s): Shengjun Yang, Philip Saul, Salvatore Mamone, Lukas Kaltschnee, Stefan Glöggler
Published in: Chemistry – A European Journal, Issue 28(8), 2021, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202104158

Metabolic Tumor Imaging with Rapidly Signal-Enhanced 1-13 C-Pyruvate-d3

Author(s): Theresa Hune, Salvatore Mamone, Henning Schroeder, Anil P Jagtap, Sonja Sternkopf, Gabriele Stevanato, Sergey Korchak, Claudia Fokken, Christoph A Müller, Andreas B Schmidt, Dorothea Becker, Stefan Glöggler
Published in: Chemphyschem : a European journal of chemical physics and physical chemistry., Issue 24(2), 2023, ISSN 1439-4235
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.202200615

Hyperpolarization of 15N in an amino acid derivative

Author(s): Philip Saul, Salvatore Mamone, Stefan Glöggler
Published in: RSC Advances, Issue 12(4), 2022, Page(s) 2282-2286, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1ra08808d

Real‐Time Metabolic Magnetic Resonance Spectroscopy of Pancreatic and Colon Cancer Tumor‐Xenografts with Parahydrogen Hyperpolarized 1‐¹³C Pyruvate‐d₃

Author(s): Lisa M. Fries, Theresa L. K. Hune, Sonja Sternkopf, Salvatore Mamone, Kim Lucia Schneider, Ramona Schulz‐Heddergott, Dorothea Becker, Stefan Glöggler
Published in: Chemistry – A European Journal, 2024, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202400187

Real-time cell metabolism assessed repeatedly on the same cells via para-hydrogen induced polarization

Author(s): Yonghong Ding, Gabriele Stevanato, Frederike von Bonin Dieter Kube, Stefan Glöggler
Published in: Chemical science., Issue 14(28), 2023, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc01350b

Rapidly Signal-enhanced Metabolites for Atomic Scale Monitoring of Living Cells with Magnetic Resonance

Author(s): Yonghong Ding, Sergey Korchak, Salvatore Mamone, Anil P. Jagtap, Gabriele Stevanato, Sonja Sternkopf, Denis Moll, Henning Schroeder, Stefan Becker, André Fischer, Ellen Gerhardt, Tiago F. Outeiro, Felipe Opazo, Christian Griesinger, Stefan Glöggler
Published in: Chemistry–Methods, Issue 2(7), 2022, ISSN 2628-9725
Publisher: Wiley-VCH
DOI: 10.1002/cmtd.202200023

Parahydrogen-enhanced pH measurements using [1-¹³C]bicarbonate derived from non-enzymatic decarboxylation of [1-¹³C]pyruvate-d₃

Author(s): Maria Daniela Santi, Theresa Luca Katrin Hune, Gonzalo Gabriel Rodriguez, Lisa M. Fries, Ruhuai Mei, Sonja Sternkopf, Josef Elsaßer, Stefan Glöggler
Published in: The Analyst, Issue 149, 2024, Page(s) 5022-5033, ISSN 0003-2654
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4an00832d

Biological <i>J</i>‐Coupling Spectroscopy at Low Magnetic Field

Author(s): Gonzalo G. Rodriguez, Charlotte von Petersdorff‐Campen, Sergey Korchak, Oscar Sucre, Maria D. Santi, Josef Elsasser, Ruhuai Mei, Lisa M. Fries, Jan Felger, Andrea Markus, Frauke Alves, Stefan Glöggler
Published in: Small Science, 2025, ISSN 2688-4046
Publisher: Wiley
DOI: 10.1002/smsc.202500268