Reverse-engineering the development of embryos with physics-informed machine learning

Project Information

DeepEmbryo

Grant agreement ID: 949267

DOI

10.3030/949267

Project closed

EC signature date 10 December 2020

Start date 1 January 2021

End date 31 March 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 957 751,00

EU contribution

€ 1 957 751,00

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Long-range mutual activation establishes Rho and Rac polarity during cell migration

Author(s): Henry De Belly, Andreu F. Gallén, Evelyn Strickland, Dorothy C. Estrada, David Sanchez Godinez, Eric Neiva, Patrick J. Zager, Tamas L. Nagy, Janis K. Burkhardt, Hervé Turlier, Orion D. Weiner
Published in: Nature Cell Biology, Issue 28, 2026, Page(s) 1244-1257, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-026-01965-1

Cell protrusions and contractions generate long- range membrane tension propagation

Author(s): Henry De Belly, Shannon Yan, Hudson Borja da Rocha, Sacha Ichbiah, Jason P Town, Patrick J Zager, Dorothy C Estrada, Kirstin Meyer, Hervé Turlier, Carlos Bustamante, Orion D Weiner
Published in: Cell, Issue 186, 2023, Page(s) 3049–3061, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2023.05.014

Blastocoel morphogenesis: A biophysics perspective.

Author(s): Mathieu Le Verge-Serandour; Hervé Turlier
Published in: Seminars in Cell & Developmental Biology, Issue 130, 2022, Page(s) 12-23, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2021.10.005

A viscous active shell theory of the cell cortex

Author(s): Hudson Borja da Rocha, Jeremy Bleyer, Hervé Turlier
Published in: Journal of the Mechanics and Physics of Solids, Issue 164, 2022, Page(s) 104876, ISSN 0022-5096
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.jmps.2022.104876

Aberrant cortex contractions impact mammalian oocyte quality

Author(s): Elvira Nikalayevich, Gaëlle Letort, Ghislain de Labbey, Elena Todisco, Anastasia Shihabi, Hervé Turlier, Raphaël Voituriez, Mohamed Yahiatene, Xavier Pollet-Villard, Metello Innocenti, Melina Schuh, Marie-Emilie Terret, Marie-Hélène Verlhac
Published in: Developmental Cell, Issue 59, 2026, Page(s) 841-852.e7, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2024.01.027

Embryo mechanics cartography: inference of 3D force atlases from fluorescence microscopy

Author(s): Sacha Ichbiah; Fabrice Delbary; Alex McDougall; Rémi Dumollard; Hervé Turlier
Published in: Nature Methods, Issue 20, 2023, Page(s) 1989–1999, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1101/2023.04.12.536641

Spatiotemporal mapping of the contractile and adhesive forces sculpting early C. elegans embryos

Author(s): Kazunori Yamamoto, Sacha Ichbiah, Matthieu Perez, Joana Borrego-Pinto, Fabrice Delbary, Nathan W. Goehring, Paul Northrop, Hervé Turlier, Guillaume Charras
Published in: Developmental Cell, Issue 61, 2026, Page(s) 1273-1288.e4, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2026.04.013

Reduction of cortical pulling at mitotic entry facilitates aster centration

Author(s): Anne Rosfelter, Ghislain de Labbey, Janet Chenevert, Rémi Dumollard, Sebastien Schaub, Zoltan Machaty, Lydia Besnardeau, Céline Hebras, Hervé Turlier, David Burgess, Alex McDougall
Published in: Journal of Cell Science, Issue 137, 2024, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1101/2023.03.21.533625

Aberrant cortex contractions impact mammalian oocyte quality

Author(s): Elvira Nikalayevich, Gaëlle Letort, Ghislain de Labbey, Elena Todisco, Anastasia Shihabi, Hervé Turlier, Raphaël Voituriez, Mohamed Yahiatene, Xavier Pollet-Villard, Metello Innocenti, Melina Schuh, Marie-Emilie Terret, Marie-Hélène Verlhac
Published in: Developmental Cell, 2024, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2024.01.027

Unfitted finite element modelling of surface-bulk viscous flows in animal cells

Author(s): Eric Neiva, Hervé Turlier
Published in: Journal of Computational Physics, Issue 560, 2026, Page(s) 114926, ISSN 0021-9991
Publisher: Academic Press
DOI: 10.1016/j.jcp.2026.114926

Conference proceedings (1)

Inverse 3D Microscopy Rendering for Cell Shape Inference with Active Mesh

Author(s): Sacha Ichbiah, Anshuman Sinha, Fabrice Delbary, Hervé Turlier
Published in: Proceedings of the IEEE/CVF International Conference on Computer Vision (ICCV), Issue October 2025, 2025, Page(s) 26987-26998
Publisher: IEEE Computer Society / Computer Vision Foundation